A comparative study to evaluate vasodilatory effect of Desflurane vs Sevoflurane using Perfusion Index

Sevoflurane and Desflurane are the most commonly used inhalational anaesthetics. These anaesthetics volatile cause dose-dependent effect on cardiovascular function, either through effects on the myocardium itself or by decreasing systemic vascular resistance (SVR) and sympathetic outflow. Perfusion index (PI) can effectively assess peripheral perfusion dynamics and vascular tone. It can be non-invasively and continuously obtained using pulse oximeter. With this background this study has been designed to compare the vasodilatory properties of Desflurane and Sevoflurane.A prospective randomized study will be conducted on 60 patients posted for surgery under general anaesthesia divided into two equal groups. Sevoflurane or Desflurane at 1.0 MAC will be used to maintain anaesthesia as per group allocation. PI will be recorded and compared in both the groups.Clinically, changes in heart rate and blood pressure are most important because, in patients at an increased risk of cardiovascular complications, both hypotension and tachycardia may cause a dramatic increase in the incidence of perioperative adverse events. PI is a novel predictor of changes in peripheral vasomotor tone. Hence, this study will help compare the two inhalational agents and find better agent with minimal perioperative adverse events due to tachycardia and hypotensionClinically,changes in heart rate and blood pressure are most important because,in patients at an increased risk of cardiovascular complications, bothhypotension and tachycardia may cause a dramatic increase in the incidence ofperioperative adverse events. PI is a novel predictor of changes in peripheralvasomotor tone. Hence, this study will help compare the two inhalational agentsand find better agent with minimal perioperative adverse events due totachycardia and hypotension.