The Effect of Bevacizumab (Avastin) on Pterygium
试验速览
- 阶段
- 2 期
- 状态
- 已完成
- 入组人数
- 5
- 试验地点
- 1
- 主要终点
- The Area the Pterygium Enlarged or Regressed as Measured From the Limbus Before and After Subconjunctival Bevacizumab Injection.
研究概览
简要总结
The purpose of this study is to determine whether local injection of bevacizumab might halt and or cause regression of pterygium growth. This may enable earlier treatment and prevention of pterygium growth into the patient's line of sight thereby limiting the need for surgery and improving quality of life for patients with pterygia.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 19 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •19 years of age and older
- •Diagnosis of pterygia
- •healthy enough to make scheduled follow-up visits
排除标准
- •Women of childbearing potential and males who plan to father a child during their participation in the study will be excluded from the study.
研究组 & 干预措施
Bevacizumab
Bevacizumab injection: 0.1ml, 6 monthly doses plus baseline and 1 week post baseline
干预措施: local injection of bevacizumab (Drug)
结局指标
主要结局
The Area the Pterygium Enlarged or Regressed as Measured From the Limbus Before and After Subconjunctival Bevacizumab Injection.
时间窗: Baseline and 3 months
Growth of the pterygium was defined as an increase in the area of the pterygium as measured from the limbus toward the visual axis. This would be a positive change value indicating progression Regression of the pterygium was defined as a decrease in the area of the pterygium length measured from the limbus toward the visual axis. This would be negative change value indicating regression.
次要结局
- Number of Patients Having Surgical Removal of Pterygium.(12 months)