To study the efficacy of Cabergoline as an adjunct to Metformin in management of overweight & obese women with PCOS

Women with PCOS have menstrual irregularities, hyperandrogenism and elevated level of inflammatory markers such as CRP , interleukins (IL-6, 18) TNF alpha, WBC count, chronic inflammatory state is further exacerbated by factors such as obesity and hyperinsulinemia, elevated level of inflammatory markers and oxidative stress indicate endothelial cell damage , Metformin alone is not as effective as in combination with other insulin sensitizer in improving glycolipid parameters in obese PCOS, Cabergoline an antiangiogenic reduces inflammatory markers in patients with prolactinoma and endometriosis. Cabergoline improves insulin sensitivity, leads to weight reduction and normalizing menstrual irregularities and androgen level in PCOS patients. We aim to evaluate the effect of add on Cabergoline with standard metformin on hormonal profile and menstrual regulation in women with overweight/obese PCOS.