MR imaging of the spinal cord in patients with spinal muscular atrophy (SMA) and healthy controls - MuSIC study

niversitair Medisch Centrum Utrecht0 个研究点目标入组 30 人开始时间: 待定最近更新: 2024年4月23日

试验速览

暂无简介。

•In order to be eligible to participate in this study, a subject must meet all of the following criteria:
•- Age 12 years or older
•- Capable of thoroughly understanding the study information given
•- Given written informed consent;Additional inclusion criteria for SMA patients:
•- A diagnosis of SMA type 2 or 3, diagnosed on clinical grounds and confirmed by homozygous deletion of the SMN1 gene;;Additional inclusion criteria for healthy volunteers:
•- Controls are healthy and do not have any history of SMA or other neuropathy related diseases;

•A potential subject who meets any of the following criteria will be excluded from participation in this study:
•- Tracheostomy, tracheostomal ventilation of any type, (non)-invasive ventilation
•- Presence of pronounced swallowing disorders or orthopnoea (which make it dangerous to lie supine in the MRI scanner)
•- Forced Vital Capacity >15% postural change between sitting and supine or symptoms of nocturnal hypoventilation (recurrent morning headaches, nightsweats, orthopneu).
•- Contra-indications for MRI (e.g. a pacemaker, claustrophobia, pregnancy)
•- Previous trauma or surgery of the (cervical) spine

发起方

niversitair Medisch Centrum Utrecht