NCT01515163Unknown不适用
Exercise and Systemic Lupus Erythematosus
适应症
试验速览
- 阶段
- 不适用
- 入组人数
- 90
- 试验地点
- 2
- 主要终点
- Lipid profile - Plasma levels of total cholesterol (mg/dl), VLDL-chol (mg/dl) HDL-chol (mg/dl), LDL-chol (mg/dl), triglycerides (mg/dl), Apolipoprotein AI and AII (mg/dl) and Apolipoprotein B (mg/dl)
研究概览
简要总结
The investigators hypothesize that a three-month aerobic exercise training program will positively affect the lipid profile, insulin sensitivity , cytokine profile, the cardiovascular parameters and muscle strength in SLE patients.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 7 Years 至 40 Years（Child, Adult）
- 性别
- Female
- 接受健康志愿者
- 否
入选标准
- •Age between 7 and 40 years
- •SLEDAI ≤ 4
排除标准
- •Cardiovascular dysfunction
- •Rhythm and conduction disorders
- •Musculoskeletal disturbances
- •Kidney and pulmonary involvements
- •Peripheral neuropathy
- •Use of tobacco
- •Treatment with lipid-lowering or hypoglycemic drugs
- •Fibromyalgia
- •Use of chronotropic or antihypertensive drugs
- •Physically active subjects
结局指标
主要结局
Lipid profile - Plasma levels of total cholesterol (mg/dl), VLDL-chol (mg/dl) HDL-chol (mg/dl), LDL-chol (mg/dl), triglycerides (mg/dl), Apolipoprotein AI and AII (mg/dl) and Apolipoprotein B (mg/dl)
时间窗: 3 months
Insulin sensitivity as measured by the Hyperinsulinemic-Euglycemic Clamp
时间窗: 3 months
Cytokine response - Plasma levels of TNF-α (pg/ml), IL-6 (pg/ml), IFN-type I (pg/ml), IL-10 (pg/ml)and IL-1ra (pg/ml)
时间窗: 3 months
次要结局
- Cardiovascular parameters(3 months)
- Muscle Strength(3 months)
研究者
Bruno Gualano
PhD, Assistant Professor
University of Sao Paulo
研究点 (2)
Loading locations...
相似试验
已完成
不适用
Exercise and Arterial Stiffness in Systemic Lupus ErythematosusSystemic Lupus ErythematosusNCT03107442Fundación Pública Andaluza para la Investigación Biomédica Andalucía Oriental58
已完成
不适用
Benefits and Tolerance of Exercise in Patients With Generalized and Stabilized Myasthenia GravisMyasthenia GravisNCT02066519Assistance Publique - Hôpitaux de Paris45
招募中
不适用
Systemic Lupus ErythematosusCognition DisorderAutoimmuneLupus Erythematosus SystemNCT05984316Biruni University30
已完成
2 期
Exercise Interventions in Parkinson's DiseaseParkinson's DiseaseNCT01439022Oxford Brookes University105
已完成
不适用
Step it Up: An Exercise and Behaviour Change Programme for People With Multiple SclerosisMultiple SclerosisNCT02301442University of Limerick65