Retrospective Study Investigating the Clinical Characteristic of Patients with Acute Presentation for Asthma to the A+E Department in a Busy Acute Hospital in England UK in Era of Biological Therapy for Asthma Between Jan 2019 & Jan 2024
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 入组人数
- 400
- 主要终点
- Change in body height
研究概览
简要总结
Study team will obtain a list of all patients who have been seen in A+E over the past 6 years with a discharge diagnosis of asthma. Their history will be reviewed from their A+E notes. Team will obtain weight and height from Electronic prescribing tool and will obtain compliance information and past medical history from participant's GP records. Team will use participant's postcode to word out socio economic status quintile using office of national statistics tool. The following information will be taken from hospital documentation and from GP records.
详细描述
- How many previous admissions in past one year (12 months)
- How many presentations to A+E in previous one year (12 months)
- Diagnosis not confirmed therefore not on any ICS
- Poor compliance (less than 75% of ICS and/or LABA and/or LAMA and/or leukotriene prescriptions picked up in past year)
- Recent presentation and maintenance therapy not increased (primary care or secondary care issue)
- Is patient overweight BMI
- Is patient on hormonal therapy, OCP, HRT, male hormones
- Social class quintile from post code of address using ONS calculator
- Ethnically diverse (see appendix)
- First Eosinophil count on index admission
- Highest eosinophil count in past (ever) and date
- Treatment for diabetes type 2
- Treatment for diabetes type 1
- Treatment for hypertension
- Smoker ever (pack year) when gave up__________
After obtaining this information study team will use simple statistical methods such as frequency and associations with confidence intervals to investigate which factors are associated with frequency of presentation to A+E. They will ascertain the frequency of patients who are on maximum therapy and may benefit from biological therapy, especially if they have raised eosinophils in the past year.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 16 Years 至 99 Years（Child, Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •All Asthmatics patients who attend Emergency department over 5 years
排除标准
- •None Asthmatics.
结局指标
主要结局
Change in body height
时间窗: 5 years
Information will be taken from hospital documentation and from GP records.
Change in body weight
时间窗: 5 years
Information will be taken from hospital documentation and from GP records.
次要结局
未报告次要终点