Effect of Obstructive Sleep Apnea Syndrome Associated With Obesity on Cough Reflex Threshold to Citric Acid
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 40
- 试验地点
- 2
- 主要终点
- To compare cough reflex threshold to citric acid between obese OSAS patients and obese non-OSAS patients
研究概览
简要总结
Up to 70% of obese patients undergoing bariatric surgery have obstructive sleep apnea syndrome (OSAS). OSAS is responsible for laryngeal sensory impairment. As the afferent neural pathway involved in the initiation of cough is located in the laryngeal epithelium, cough reflex sensitivity may be decreased in obese OSAS patients. The researchers therefore conducted this study to determine the effect of OSAS associated with obesity on cough reflex sensitivity, assessed by cough reflex threshold to an inhaled irritant (citric acid).
详细描述
Obese patients undergoing scheduled bariatric surgery underwent a cough challenge as part of their routine preoperative evaluation. Patients were classified as presenting OSAS if apnea-hypopnea index obtained from preoperative full-night polysomnography was greater than 5/hour. Cough threshold was measured with citric acid. Increasing concentrations of mouth- nebulized citric acid (2.5, 5, 10, 20, 40, 80, 160, 320 and 640 mg/mL) were delivered during inspiration until a cough was elicited. The citric acid concentration eliciting one cough (C1) was defined as the cough reflex threshold.
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Single Group
- 主要目的
- Diagnostic
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Obese patient scheduled to undergo bariatric surgery
排除标准
- •Age less than 18
- •Active smoking
- •Psychotropic medication
- •Angiotensin-converting enzyme inhibitor or angiotensin II receptor antagonist medication
- •Pregnancy
- •Anesthesia or endotracheal intubation during the previous month
- •Allergic rhinitis
- •Upper airway or bronchopulmonary infection during the previous month
- •Chronic cough
- •Chronic respiratory disease
- •Pharyngolaryngeal disease
- •Neurological disease
结局指标
主要结局
To compare cough reflex threshold to citric acid between obese OSAS patients and obese non-OSAS patients
次要结局
- To correlate OSAS severity assessed by apnea-hypopnea index and cough reflex threshold to citric acid