Phase 2 Study of Randomized Controlled Trial of Pancreatic Enzyme Supplementation in Patients With Unresectable Pancreatic Cancer
试验速览
- 阶段
- 2 期
- 状态
- 已完成
- 入组人数
- 67
- 试验地点
- 1
- 主要终点
- the change in body weight at eight weeks after the randomisation
研究概览
简要总结
The investigators planned a prospective, randomized, placebo controlled trial to test the hypothesis that weight loss in patients with unresectable pancreatic cancer with occlusion of the pancreatic duct can be reduced or prevented by pancreatic enzyme replacement therapy in combination with dietary counseling.
详细描述
Pancreatic cancer has the worst overall prognosis with fewer than 3% of affected patients alive five years after the initial diagnosis. It is the fourth leading cause of death from cancer in Korea. 80-90% of patients have locally unresectable or advanced metastatic disease and for these patients only palliative treatment options remain. Symptoms include obstructive jaundice, duodenal obstruction, pain, and weight loss. Palliative treatment is mainly directed against the former three. Interventions to prevent (further) weight loss have as yet received little or no attention, in spite of the frequent occurrence of this symptom. About 90% of patients with pancreatic carcinoma have weight loss at the time of diagnosis. In addition, Weight loss prior to chemotherapy was found to have a prognostic effect on survival in a range of different tumor types.
There is a limited range of studies investigating the incidence of exocrine insufficiency in pancreatic cancer. Studies available indicate a high incidence of exocrine insufficiency in unresectable pancreatic cancer patients and patients before and after pancreatic cancer surgery. The previous reports showed that 68-92% of pancreatic cancer patients were exocrine insufficient. Such high incidences of exocrine insufficiency in pancreatic cancer patients support the use of pancreatic enzyme replacement therapy in this patient group. The guidelines for the management of patients with pancreatic cancer periampullary and ampullary carcinoma published in Gut promote the use of pancreatic enzyme replacement therapy to maintain weight and to increase quality of life in this patient group. However, studies evaluating the efficacy of pancreatic enzyme replacement therapy in pancreatic cancer are lacking to date. There have been no systematic reviews and only one randomized control trial involving a small sample of 21 patients with unresectable cancer of the pancreatic cancer.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Triple (Participant, Care Provider, Investigator)
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •To be eligible for inclusion, each patient must fulfill each of the following criteria:
- •Subjects with unresectable pancreatic cancer preferably proven by cytology or histology
- •not eligible for surgery because of poor general condition, local unresectability, or advanced disease with metastases
- •Age over 18 years old
- •Performance status (ECOG scale): 0-2
- •Agree to record daily food intake
- •Patients should sign a written informed consent before study entry
排除标准
- •Patients will be excluded from the study for any of the following reasons:
- •History of major gastrointestinal surgery
- •history of chronic gastrointestinal disease (for example, Crohn's disease)
- •Diabetes decompensated
- •Diabetes mellitus with severe gastroparesis
- •presence of pancreatic pseudocysts impeding gastric or duodenal passage
- •any use of antacids, mucosal protective agents, H 2 receptor antagonists, or proton pump inhibitors that could not be discontinued
- •concomitant medication affecting gastroduodenal motility (e.g. metoclopramide and erythromycin), or interfering with bile secretion (e.g. bile acids)
- •Abusive use of alcohol in the three months preceding the study;
- •known allergy to pancreatin
- •Any major surgery within 4 weeks prior to study treatment
- •Pregnant or lactating woman
- •Any patients judged by the investigator to be unfit to participate in the study
研究组 & 干预措施
pancreatic enzyme replacement therapy
The pancreatic enzyme preparation under investigation is Norzyme ® 6 - 9 tablets per day.
干预措施: Norzyme (Drug)
结局指标
主要结局
the change in body weight at eight weeks after the randomisation
时间窗: at baseline and 4, 8 week, 24 week
the percentage change in body weight at eight weeks after the randomisation
次要结局
- Frequency and intensity of abdominal pain daily(at baseline and 4, 8 week, 24 week)
- Frequency of bowel movements per day(at baseline and 4, 8 week, 24 week)
研究者
Sang Myung Woo
Staff physician, Ceneter for Liver Cancer
National Cancer Center, Korea