PET Imaging and Bariatric Surgery
试验速览
- 阶段
- 1 期
- 状态
- 已完成
- 入组人数
- 7
- 试验地点
- 1
- 主要终点
- Regional DRD2/3 Binding Percent Changes After Bariatric Surgery
研究概览
简要总结
The purpose of this study is to look at certain areas of the brain that are related to addictive behaviors, such as overeating. These areas are called 'dopamine type 2 receptors' (DRD2/3) and other studies have shown that obese people have less of these. We propose that low DRD2/3 availability seen in morbidly obese subjects will change with weight loss associated with bariatric surgery.
详细描述
The purpose of this study is to look at certain areas of the brain that are related to addictive behaviors, such as overeating. These areas are called 'dopamine type 2 receptors' (DRD2/3) and other studies have shown that obese people have less of these. We propose that low DRD2/3 availability seen in morbidly obese subjects will change with weight loss associated with bariatric surgery.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 60 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Ages 18-60 years
- •BMI equal to or greater than 40, or equal to or greater than 35 if there are 2 or more co-morbidities
- •Weight less than 350 pounds
排除标准
- •History of substance abuse,including but not limited to alcohol, cocaine, marijuana, heroin, nicotine
- •History of psychiatric disorders
- •Use of any antidepressants or psychotropics in the past 12 months
- •Diabetes Mellitis
- •Positive pregnancy test
- •Any condition felt by the PI or co-investigators to interfere with the individual's ability to complete the study
- •Subjects on medications for the last 3 months, such as sibutramine, which could affect the quality of the study, as determined by the PI
- •Inability to travel to Nashville, TN four times
研究组 & 干预措施
F-18 (fallypride)
Subjects undergoing bariatric surgery will have Positron Emission Tomography (PET) scans of their brains using F-18 (fallypride), a dopamine type 2/3 (DA D2/3) receptor radioligand whose binding is sensitive to competition with endogenous dopamine, before and after the operation.
干预措施: F-18 (fallypride) (Drug)
结局指标
主要结局
Regional DRD2/3 Binding Percent Changes After Bariatric Surgery
时间窗: ~7 weeks
次要结局
未报告次要终点
研究者
Julia P.Dunn,MD
Physician
Vanderbilt University Medical Center