What Are the Determinations of Adult Progressive CKD? The Renal Impairment In Secondary Care (RIISC) Study
试验速览
- 阶段
- 不适用
- 状态
- 进行中（未招募）
- 发起方
- 入组人数
- 932
- 试验地点
- 1
- 主要终点
- Number of participants not alive
研究概览
简要总结
Chronic kidney disease (CKD) affects up to 16% of the adult population and is associated with significant morbidity and mortality. People at highest risk from progressive CKD are defined by a sustained decline in estimated glomerular filtration rate (eGFR) and/or the presence of significant albuminuria/proteinuria. Accurate mapping of the bio-clinical determinants of this group will enable improved risk stratification and direct the development of better targeted management for people with CKD. To address these requirements we have established the Renal Impairment in Secondary Care (RIISC) study; RIISC is enrolling a cohort of patients at high risk from progressive CKD and compiling a comprehensive and detailed bio-clinical phenotype, including vascular and oral health phenotyping, at enrolment and on subsequent follow-up.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Decline of eGFR of ≥5mls/min/year or ≥10mls/min/5years
- •and/or urinary albumin-creatinine ration (ACR) ≥70 mg/mmol on three occasions
- •and/or CKD 4 or 5 (pre-dialysis)
排除标准
- •renal replacement therapy
- •immunosuppression
结局指标
主要结局
Number of participants not alive
时间窗: up to 10 years
次要结局
- Number of participants who reach End Stage Kidney Disease(up to 10 years)
研究者
Paul Cockwell
Consultant Nephrologist
University Hospital Birmingham NHS Foundation Trust