Predictors of Disease Free Survival After Curative Cancer Rectum Surgery
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 200
- 试验地点
- 1
- 主要终点
- Tumor recurrence
研究概览
简要总结
Tumor recurrence after curative surgical resection for rectal cancer is a serious complication that greatly affects the overall morbidity and the outcome. This study aims to identify the different prognostic factors affecting recurrence and disease-free survival after surgery.
详细描述
A retrospective analysis of patients operated for cancer rectum with curative intent from.
Exclusion criteria will include patients with familial adenomatous polyposis, multiple synchronous or metachronous rectal cancers, and death within 3 months. Incomplete patients' files and patients that lost follow-up will be excluded.
Demographic, histopathological, follow up and outcome data will be collected from completed patients' files. Demographics include age, gender, family history, and chief complaint at the presentation. Histopathological data include tumor grade, vascular-perineural invasion, the total number of lymph nodes removed, and positive lymph nodes.
Lymph node ratio will be defined as the ratio of positive lymph nodes to the total number of retrieved lymph nodes in a histopathology specimen. Disease-free survival will be calculated for each patient based on the time of surgery to the time of recurrence detection.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 18 Years 至 90 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients who had curative surgery for cancer rectum.
排除标准
- •Patients with familial adenomatous polyposis (FAP), multiple synchronous or metachronous rectal cancers, and death within 3 months
- •Patients that lost follow-up will be excluded.
结局指标
主要结局
Tumor recurrence
时间窗: Through study completion, an average of 3 year
Presence of Tumor recurrence after curative surgery for cancer rectum.
Disease free survival.
时间窗: up to 5 years
From date of surgery until the date of recurrence detection.
次要结局
未报告次要终点
研究者
Abdallah Mohamed Taha Aly
Assistant Professor of general Surgery
South Valley University