Quadriceps Motor Unit Adaptation to Simulated Knee Injury
试验速览
- 阶段
- 1 期
- 状态
- 招募中
- 入组人数
- 45
- 试验地点
- 1
- 主要终点
- Motor Unit Recruitment (amplitude relative to recruitment threshold)
研究概览
简要总结
This study investigates how simulated knee injury-via artificial joint effusion or deafferentation-affects quadriceps motor unit behavior in healthy young adults. Participants will complete neuromuscular testing during a single 2-hour lab session. This research seeks to improve understanding of muscle inhibition and inform interventions after real-world knee trauma.
详细描述
Using a controlled laboratory model, the investigators will simulate knee injury through two methods: (1) intra-articular saline injection to induce effusion, and (2) intra-articular lidocaine injection to induce sensory deafferentation. Healthy participants aged 18-30 will undergo surface and decomposition EMG, isometric strength testing, and reflex measurements before and after the intervention. The primary outcome is motor unit recruitment characteristics, with secondary outcomes including quadriceps inhibition (Hoffmann reflex) and isometric peak torque. The findings will inform future neuromodulatory approaches in rehabilitation.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Basic Science
- 盲法
- Single (Participant)
入排标准
- 年龄范围
- 18 Years 至 30 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Age 18-30 years
- •Physically active (Tegner ≥ 5)
- •No prior lower-limb surgery or major injury
排除标准
- •Lower limb surgery or significant injury in past 2 years
- •Cardiopulmonary, neurological, or psychiatric disorders
- •Needle/electrical stimulation anxiety
- •Medications affecting neuromuscular or psychological function
- •Allergic to lidocaine
- •Inability to elicit Hoffmann reflex
研究组 & 干预措施
Effusion Group
60 mL sterile saline injected into knee
干预措施: Joint Effusion via 60 mL Sterile Saline (Device)
Deafferentation Group
Lidocaine (single intra-articular dose)
干预措施: Intra-articular Lidocaine (Drug)
Control Group
Sham procedure with fake needle
干预措施: Sham injection (Other)
结局指标
主要结局
Motor Unit Recruitment (amplitude relative to recruitment threshold)
时间窗: Baseline, 0, 30, and 60 minutes post-intervention
Measured via surface EMG decomposition
Motor Unit Recruitment (firing rate relative to recruitment threshold)
时间窗: Baseline, 0, 30, and 60 minutes post-intervention
Measured via surface EMG decomposition
次要结局
- Quadriceps Inhibition (Hoffmann Reflex)(Baseline, 0 and 60 minutes post-intervention)
- Isometric Peak Torque (Quadriceps Strength)(Baseline and 60 minutes post-intervention)
研究者
Grant Norte
Associate Professor
University of Central Florida