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临床试验/CTRI/2025/10/095574
CTRI/2025/10/095574尚未招募不适用

Comparative Clinical Evaluation Of Varnya Mahakshaya Ksheer-Paka Nasya And Its Lepa In Vyanga (Melasma)

Uttarakhand Ayurved University1 个研究点 分布在 1 个国家目标入组 60 人开始时间: 2025年10月13日最近更新:

试验速览

阶段
不适用
状态
尚未招募
发起方
入组人数
60
试验地点
1
主要终点
No improvement- 0%-25%

研究概览

简要总结

Melasma is a skin condition marked by dark brown patches that appear symmetrically on sun-exposed areas of the face, resulting from an excess of melanin. The reasons behind melasma, most significant cited factor is sunlight exposure, followed by childbirth, oral contraceptive pills use, endocrine issues, particularly thyroid abnormalities, cosmetics use, medication use, especially anticonvulsants and photosensitizing agents and genetic impacts. Vyanga Can be compared with Melasma, a prevalent skin condition that causes brown grey spots or bluish grey discoloration on the face, usually on the cheeks, forehead, chin and nasal bridge. In Ayurveda  is classified under Kshudra Rogaand can be distinguished by the Niruja and Shyava Varna Mandals that are present on the face. Vata and Pitta are the Doshas that are involved in causing Vyanga and they are exaggerated by Krodha, AayasaandShoka. If we look at the treatment approach several therapy procedures has specified by the Acharyas like Abhyanga, Lepa,Pradeha, Shamana Nasya, Siraveda, Vamana and Virechana. Therefore, Ksheer-Paka Nasya and LepaofVarnya Mahakashayawill be used as medication in current study as they are Raktaprasadana, Pitta ShamakaandVatahara.

研究设计

研究类型
Interventional
分配方式
Randomized
盲法
None

入排标准

年龄范围
20.00 Year(s) 至 50.00 Year(s)(—)
性别
All

入选标准

  • Patient fulfilling the diagnostic criteria of Vyanga.
  • Patient of age between 20 years to 50 years.
  • Sex- both female and male.
  • Patient fit for Nasya Karma and Lepa.

排除标准

  • Skin diseases of face other than Melasma (Vyanga).
  • Hyperpigmentation since birth.
  • Ex- Nervous of ota.
  • Subjects with local inflammatory skin disorders such as herpes infection.
  • Known cases of allergies skin disease of face.
  • Uncontrolled diabetes mellitus and previously diagnosed life threatening and complicated systemic diseases.
  • Known case of Polycystic ovary disorder (PCOD)
  • Pregnant and lactating women.

结局指标

主要结局

No improvement- 0%-25%

时间窗: 15th, 29th, 42th day

Mild improvement- 25%-50%

时间窗: 15th, 29th, 42th day

Moderate improvement- 50%-75%

时间窗: 15th, 29th, 42th day

Marked improvement- 75%-100%

时间窗: 15th, 29th, 42th day

次要结局

  • Exacrebation in sign and symptoms(42 days)

研究者

发起方
Uttarakhand Ayurved University
申办方类型
Government medical college
责任方
Principal Investigator
主要研究者

Dr Pravesh Kumar Mukeriya

Rishikul Campus Haridwar, Uttarakhand Ayurved University

研究点 (1)

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