Analysis of the effect of tricyclic antidepressants for herpes zoster pain or post herpetic neuralgia for the QTc interval on electrocardiogram. - Analysis of the effect of tricyclic antidepressants for analgesic adjuvant on the QTc interval.

Eighty-seven patients were analysed. The analgesic dosages of TCAs significantly prolonged QTc interval(delta QTc, 6.7 +- 16.1 ms). Although 15 patients were categorized as having abnormal QTc prolongation, there were no dangerous cases such as QTc > 500 ms or delta QTc > 60 ms. In multivariate logistic analysis, Left ventricular hypertrophy was detected as independent risk factor for abnormal QTc prolongation (OR 4.09; 95% CI 1.01-16.55, p=0.04).