Influence of Hesperidin and Vitamin C on Uric Acid Concentration
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 40
- 试验地点
- 2
- 主要终点
- Changes in uric acid serum concentrations
研究概览
简要总结
Aim of the study is to investigate the impact of hesperidin and/or vitamin C on elevated uric acid concentrations.
详细描述
Duration of the study is 9 weeks. 1) a washout week, 2) two intervention weeks, 3) four weeks washout period, 4) two intervention weeks.
The study is conducted under free living conditions. During washout weeks consumption of orange juice or citrus fruits or vitamin C containing supplements is restricted.
During intervention weeks 200 mL of study drink is consumed daily. And participants are asked to maintain their normal physical activity and habitual diet. Additional citrus or vitamin C containing beverages are not allowed.
At the beginning and the end of each intervention phase uric acid, insulin sensitivity, blood pressure, pulse wave velocity and bioavailability of hesperidin are assessed.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Basic Science
- 盲法
- Double (Participant, Investigator)
入排标准
- 年龄范围
- 20 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •higher uric acid concentration (≥5.5 mg/dL)
- •Informed written consent
排除标准
- •pregnancy
- •fructose intolerance
- •gout or medicated hyperuricemia
- •diabetes mellitus
- •antidiabetic or cytostatic medication
- •weight loss (≥5% in the past 3 months)
- •consumption of vitamin C-containing supplements
- •parallel participation in a clinical trial
- •anemia and / or iron deficiency
结局指标
主要结局
Changes in uric acid serum concentrations
时间窗: Baseline (pre) and post two weeks of intervention
measured via uric acid serum concentration (mg/dL)
次要结局
- changes in pulse wave velocity(Baseline (pre) and post two weeks of intervention)
- insulin sensitivity(Baseline (pre) intervention periods)
- changes in uric acid excretion(Baseline (pre) and post two weeks of intervention)
研究者
Prof. Dr. Dr. Anja Bosy-Westphal
Prof. Dr. Dr. Anja Bosy-Westphal
University of Kiel