NCT00507806终止1 期
Microbubble-Enhanced Clotbust Treatment of Acute Ischemic Stroke
ImaRx Therapeutics0 个研究点开始时间: 2005年3月1日最近更新:
适应症
相关药物
试验速览
- 阶段
- 1 期
- 状态
- 终止
- 发起方
- 主要终点
- Incidence of symptomatic intracranial hemorrhage
研究概览
简要总结
The study is designed to examine the safety, tolerability, and activity of a combination of microbubbles (perflutren lipid microsphere [Definity®]) and continuous monitoring with 2 MHz transcranial Doppler ultrasound (TCD) as an adjunctive therapy to tissue plasminogen activator (tPA) treatment in subjects with acute ischemic stroke.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Measurable focal neurological deficit (National Institutes of Health Stroke Scale [NIHSS] score > 4 points)
- •tPA eligible
- •Occlusion of the middle cerebral artery
排除标准
- •Right to left cardiac shunt
- •Uncontrolled hypertension
- •Absent temporal windows
结局指标
主要结局
Incidence of symptomatic intracranial hemorrhage
时间窗: 72 hours
次要结局
- Complete recanalization of the occluded artery (TIBI 4-5)(End of treatment)
- NIHSS score of 0-2(24 hours)
- Favorable outcome (modified Rankin Scale or NIHSS 0-1)(3 months)
研究者
相似试验
已完成
2 期
Sonothrombolysis Potentiated by Microbubbles for Acute Ischemic StrokeCerebrovascular StrokeNCT01678495Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau24
Unknown
1 期
Safety Study of Combining Ultrasound Microbubbles and Chemotherapy to Treat Malignant Neoplasms of Digestive SystemGastrointestinal NeoplasmsNCT02233205Peking University Cancer Hospital & Institute18
终止
2 期
Microbubbles and Ultrasound in Stroke Trial: MUST StudyAcute Ischemic StrokeNCT00222040University Hospital, Toulouse20
Unknown
1 期
Busulfan, Melphalan, Escalating Carfilzomib Conditioning Auto Stem Cell Transplantation for Multiple Myeloma (MM)Multiple MyelomaNCT03795597Loyola University36
已完成
2 期
Safety and Efficacy of Methylene Blue Combined With Amodiaquine or Artesunate for Malaria Treatment in Children of Burkina FasoMalariaNCT00545935Heidelberg University186