Short Term Effect of Empagliflozin on Left Ventricular Relaxation in Non Diabetic Hypertensive Patients
试验速览
- 阶段
- 4 期
- 状态
- 已完成
- 发起方
- 入组人数
- 15
- 试验地点
- 2
- 主要终点
- Left ventricular diastolic function
研究概览
简要总结
The investigators assessed the 6-week effect of once daily 25mg SGLT2-i Empagliflozin on left ventricular diastolic function and blood pressure profile in non diabetic hypertensive patients
详细描述
Background: The rapid beneficial effects of Empagliflozin on cardiovascular mortality and hospitalizations rates for heart failure according to the Cardiovascular Outcome Event Trial in Type 2 Diabetes Mellitus Patients (EMPA-REG OUTCOME) trial raise some question in the mechanism of myocardial action. The investigators conducted this study in a population of non-diabetic hypertensive patients in order to look for a short-term effect on left ventricular relaxation.
Methods: The investigators carried out a single arm non- randomized clinical trial and assigned patients to receive 25mg of empagliflozin once daily in additional therapy for six weeks at the National Center for Obesity and in the cardiology department of Yaounde Central Hospital in hypertensive patients with cardiac relaxation disorder. The objectives were to evaluate the left ventricular diastolic function and nycthemeral blood pressure profile.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 21 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Grade 1 hypertension
- •Grade 1 or 2 relaxation abnormalities (Doppler E/A ratio <1)
- •Unchanged antihypertensive treatment for at least 12 weeks
排除标准
- •Diabetes mellitus
- •eGFR < 60 mL/min/1,73 m²
- •Mitral stenosis
- •Atrial fibrillation
- •Alanine transferase above 2N
研究组 & 干预措施
Intervention
Empagliflozin 25mg daily add-on therapy
干预措施: Empagliflozin Tablets (Drug)
结局指标
主要结局
Left ventricular diastolic function
时间窗: 6 weeks
Doppler ultrasound measured relaxation
次要结局
- HbA1c(6 weeks)
- Blood pressure(6 weeks)
研究者
Sobngwi Eugene
Medical Advisor
Yaounde Central Hospital