Action of Glycation and Inflammation in Operative Ischemic Heart Disease
试验速览
- 阶段
- 不适用
- 状态
- 终止
- 发起方
- 入组人数
- 16
- 试验地点
- 1
- 主要终点
- Identification of Glycation Biomarkers (MGO) linked to ischemic event and outcome
研究概览
简要总结
This study requires the consecutive enrollment of 60 patients following the first event of acute myocardial infarction, evaluating B-Cell Activating Factor (BAFF) and methylglyoxal (MGO) levels in the acute setting (pre-reperfusion) and 3 months after reperfusion.
详细描述
This study requires the consecutive enrollment of 60 patients at admission for first acute myocardial infarction. At enrollment, before reperfusion, a blood sample is obtained to measure B-Cell Activating Factor (BAFF) and methylglyoxal (MGO) levels in the acute setting. This measure is then repeated at follow-up visit 3 months after reperfusion. The aim of the study is to identify specific subsets of patients and evaluate biomarkers variations.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •hospitalization for first myocardial infarction (STEMI or NSTEMI)
- •age between 18 and 80
排除标准
- •uncompensated T2DM (HbA1c >53mmol/mol)
- •use of anti-CD20 treatment
- •chronic anti-inflammatory treatment for autoimmune disease (i.e. DMARDs, high dose FANS, cortisonic drugs)
结局指标
主要结局
Identification of Glycation Biomarkers (MGO) linked to ischemic event and outcome
时间窗: Day 0
elevation of MGO levels
Identification of Inflammatory Biomarkers (BAFF) linked to ischemic event and outcome
时间窗: Day 0
elevation of BAFF levels
次要结局
- Identification of biomarkers variations (BAFF) complications and outcome(After 3 months)
- Identification of biomarkers variations (MGO) complications and outcome(After 3 months)