Association Between Early Postoperative L-Arginine Administration and Acute Kidney Injury Following Cardiac Surgery
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 5,135
- 试验地点
- 2
- 主要终点
- incidence of postoperative AKI
研究概览
简要总结
To investigate the association between the the early administration of L-Arginine after CPB-assisted cardiac surgery and the incidence of CS-AKI in adult patients. To test if it can reduce the incidence of post-operative AKI.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •adult patients (over 18 years)
- •underwent CPB assisted cardiac surgery
- •admitted to ICU
排除标准
- •congenital heart disease
- •underwent deep hypothermic circulatory arrest (DHCA)
- •with glomerular filtration rate (eGFR) below 30 mL/min/1.73 m²
研究组 & 干预措施
Without Arginine
No L-arginie was administered
Arginine Use
At least one dose of L-arginie was administered in the early postoperative stage
干预措施: L-Arginine hydrochloride (Drug)
结局指标
主要结局
incidence of postoperative AKI
时间窗: from the time of end of surgery until time of documented hospital discharge or time of death, whichever came first, assessed up to 30 days
Serum Creatinine Criteria: Increase in Serum Creatinine: An absolute increase in serum creatinine of 0.3 mg/dL (26.5 µmol/L) within 48 hours. OR a percentage increase in serum creatinine of ≥50% within 7 days. These criteria are relative to the baseline creatinine level, which is usually the recent preadmission value. Urine Output Criteria: Oliguria, defined as a urine output \<0.5 mL/kg/h for more than 6 hours. OR anuria, defined as a urine output \<100 mL in 24 hours.
次要结局
- length of in-hospital stay(from the time of end of surgery until time of documented hospital discharge or time of death, whichever came first, assessed up to 30 days)
- Renal failure(from the time of end of surgery until time of documented hospital discharge or time of death, whichever came first, assessed up to 30 days)
- in-hospital mortality(from the time of end of surgery until time of documented hospital discharge or time of death, whichever came first, assessed up to 30 days)
研究者
Chong Lei, MD & phD
Principal Investigator
Xijing Hospital