Chemotherapy of first line reinforced for cancers of the colonist and the rectum with hepatic and/or pulmonary metastases potentially résécables: Strong association FOLFIRI and ERBITUX - ERBIFORT

niversityHospitalGrenoble0 个研究点开始时间: 2007年6月20日最近更新: 2012年3月19日

适应症

试验速览

暂无简介。

•Will be proposed for the study the subjects answering each following criterion: Index of performance WHO 18 years
•Rectal Adenocarcinomist colic or with hepatic metastases (synchronous or métachrones) not résécables of start: - Less than 8 hepatic metastases and less than 6 hepatic segments reached - Not more than 2 extra-hepatic metastatic sites potentially résécables
•Visceral metastases potentially résécables if tumoral regression after chemotherapy
•Cancer (primitive and/or metastases) histologically proven
•Immediate Non-resecability reserve by a hépato-biliary surgeon at a multidisciplinary conciliation meeting
•At least a measurable supra-centimetric metastasis by helicoid tomodensitometry and/or IRM
•Life expectancy 3 months
•Bilirubine 1500/mm3, plates 100 000/mm3
•Creatinin 60 ml/min
•Rate of Prothrombine 70 %
•Enlightened assent
•Possible follow-up
•Nobody affiliated with the social security or profit of such a mode
•Are the trial subjects under 18? no
•Number of subjects for this age range:
•F.1.2 Adults (18-64 years) yes
•F.1.2.1 Number of subjects for this age range
•F.1.3 Elderly (>=65 years) yes
•F.1.3.1 Number of subjects for this age range

•could not be included the subjects answering at least one of the following criteria:
•More than 6 hepatic segments reached of metastases
•More than 2 extra-hepatic metastatic sites or not obvious resecability of extra-hepatic metastases
•Cerebral metastases or carcinomatous meningitis of cancer colorectal
•Carcinose péritonéale or c?liaque ganglionic extension
•Osseous metastases?
•Antecedents of another malignant tumour (except cutaneous cancers basocellulaires or in situ cancers of the uterine collar)
•Co-morbidity considered to be too important or contra-indicating chemotherapy (or the surgical résection of metastases (for example: angor unstable, symptomatic cardiac insufficiency)
•Pregnant woman parturient, mother who nurses
•Antecedents of anti-cancer chemotherapy (except an auxiliary chemotherapy if it has been finished for at least 3 months)Inclusion in another therapeutic test requiring the realization of other treatments that those of this study
•Nobody private of freedom by court order or administrative, anybody being the subject of a legal protection measure,

发起方

niversityHospitalGrenoble