Mindful Self-Compassion for Anxiety Disorders and Depression
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 40
- 试验地点
- 1
- 主要终点
- Hospital Anxiety and Depression Scale
研究概览
简要总结
The study will compare 8-week Mindful Self-Compassion training, compared to a control group that does not receive the intervention, on anxiety and depression symptom severity in patients with diagnosed anxiety disorders (generalized anxiety disorder, social anxiety disorder, and panic disorder) or major depressive disorder.
详细描述
Anxiety disorders, such as generalized anxiety disorder, social anxiety disorder, and panic disorder, and depressive disorders result in significant distress, impairment in social and occupational functioning and increased risk for suicide. While there are medication and psychotherapy treatment options, they can sometimes be difficult to access and may be ineffective for a proportion of the population. Also, many patients are reluctant to take psychiatric medication, and many prefer to avoid psychiatric care altogether due to stigma or distrust of medical care settings such as a psychiatry clinic. Mindfulness meditation training can be provided outside of a medical care setting and may be more acceptable and feasible for some patients.
One way that mindfulness meditation may provide unique benefits for anxiety and depression is through decreasing self-judgment and increasing self-compassion. Research has shown that people with anxiety disorders, for example, have lower levels of self-compassion than people without anxiety. This is consistent with theories about the development and phenomenology of anxiety disorders, which are characterized as having high levels of self-criticism. Mindfulness-based interventions have been shown to improve self-compassion and self-acceptance.
In this study, patients with anxiety disorders or depression will be randomized to either an 8-week class called Mindful Self-Compassion training or a group that does not receive treatment.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Single (Investigator)
盲法说明
The study investigator will be masked to treatment assignment.
入排标准
- 年龄范围
- 18 Years 至 75 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Must have a primary anxiety disorder (social anxiety disorder, generalized anxiety disorder, panic disorder, or agoraphobia) or major depressive disorder, current
- •Must score low on self-compassion, as measured by the self-compassion scale
- •Must understand study procedure and willing to participate in all testing visits, and treatment as assigned
- •must be able to give informed consent to the study procedures
排除标准
- •Comorbid psychiatric disorder other than anxiety or depression, such as psychotic disorder, obsessive compulsive disorder, eating disorders (i.e., anorexia and bulimia), bipolar disorder; developmental or organic mental disorders; and current (past 6 months) substance use disorders and current post-traumatic stress disorder as assessed by clinician at screening visit
- •A serious medical condition that may result in surgery or hospitalization.
- •A history of head trauma causing prolonged loss of consciousness, or ongoing cognitive impairment
- •Inability to understand study procedures or informed consent process, or significant personality dysfunction likely to interfere with study participation (assessed during the clinical interview).
- •Subjects who will be non-compliant with the study procedures. This may include planned travel out of town.
- •Subjects taking some psychiatric medication such as barbiturates or antipsychotics. Sleep medications and some anti-depressants will be allowed, if the subject has been taken at stable dose 8 weeks prior to baseline and the patient plans to continue at the same dose through the trial.
- •Concurrent psychotherapy initiated within 1 month of screen interview, or ongoing psychotherapy of any duration directed specifically toward the treatment of anxiety (such as Cognitive Behavioral Therapy).
- •Individuals who have completed a course of MSC or an equivalent meditation training in the last year.
- •Individuals reporting significant active suicidal ideation or suicidal behaviors within the past year.
- •Individuals with a medical condition (i.e., epilepsy) that may be exacerbated by study treatment, as determined by a study physician or nurse practitioner based on history, physical, and/or labs.
- •Adults unable to consent
- •Pregnant women
- •Prisoners
研究组 & 干预措施
Mindful Self-Compassion
Mindful Self-Compassion (MSC) is a weekly class given for 8 weeks. The individual classes last about 2 hours each. The class is provided in a group setting.
干预措施: Mindful Self-Compassion (Behavioral)
Treatment as Usual (TAU)
The TAU arm will not receive the additional treatment from the study. Subjects will receive psychiatric treatment from their usual providers.
结局指标
主要结局
Hospital Anxiety and Depression Scale
时间窗: 8 weeks
Self-report questionnaire of anxiety and depression symptoms, 14 items using 4-point likert scale
次要结局
- Self-compassion Scale(8 weeks)
- Liebowitz Social Anxiety Scale - Self-Report(8 weeks)
- PROMIS-Anxiety-Short form(8 weeks)
- PROMIS-Depression-Short Form(8 weeks)
研究者
Elizabeth Hoge
Professor of Psychiatry
Georgetown University