NCT01177709终止不适用
Evaluation of the Efficacy of Metformin for Weight Loss and Metabolic Effects In Overweight Psychiatric Patients Treated With Antipsychotic Medication
适应症
干预措施
相关药物
试验速览
- 阶段
- 不适用
- 状态
- 终止
- 入组人数
- 12
- 试验地点
- 1
- 主要终点
- Weight (wt) in Pounds (Lbs)..
研究概览
简要总结
Study hypothesis is that patients on antipsychotics medication treated with metformin will show loss in weight and improved measures of glucose metabolism.
详细描述
Patients who had gained more than 10 lbs of weight in the last 3 months or had BMI of 35 or greater were treated with metformin up to 2500 mg/day in an open label study of up to 3 months time. Changes in weight and glucose measures were recorded.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 70 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients will be 18-70 years of age;
- •Currently hospitalized or an outpatient at MPC;
- •BMI ≥ 35 or excessive recent weight gain ( > than 10 lb weight gain in the past 3 months);
- •Patients will have a diagnosis of schizophrenia or schizoaffective disorder or bipolar disorder.
排除标准
- •Age below 18 or over 70;
- •Patient is currently already treated with metformin.
研究组 & 干预措施
Metformin
Experimental
干预措施: Metformin (Drug)
结局指标
主要结局
Weight (wt) in Pounds (Lbs)..
时间窗: baseline, 4 weeks, 8 weeks, 12 weeks
Patients weight in pounds
次要结局
- Glucose Levels(baseline, 4 weeks, 8 weeks, 12 weeks)
- Insulin Level(baseline, 4 weks, 8 weeks, 12 weeks)
研究者
Robert C. Smith MD PhD
Research Psychiatrist-Principal investigator
Nathan Kline Institute for Psychiatric Research
研究点 (1)
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