NCT05776485已完成不适用
Protein Turnover in Healthy and Overuse-diseased Tendon
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 36
- 试验地点
- 1
- 主要终点
- Protein turnover in tendon tissue from patients with chronic tendinopathy compared to healthy controls
研究概览
简要总结
The goal of this clinical trial is to examine the regional protein turnover in tendon tissue from patients with chronic patellar tendinopathy and comparing this to healthy controls. Further we will examine the effect of resistance training on protein turnover in healthy individuals.
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Parallel
- 主要目的
- Basic Science
- 盲法
- Single (Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 40 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Physical active men and women
- •Body mass index 18,5 - 30 kg/m2
- •Inclusion Criteria for the chronic tendinopathy group:
- •Debut of symptom > 90 days prior to inclusion.
- •Subjective activity related pain in patella tendon.
- •Clinical symptoms of patella tendinopathy.
- •Ultrasound verification of at least 1 in three of the following: Enchanced anterior-posterior diameter, increased Doppler signal and/or a hypoechoic area in the diseased part of the tendon.
- •Exclusion Criteria for all participants:
- •Former knee surgery or injuries to the patella tendon.
- •Local injection of corticosteroids within 12 months.
- •Medication that affects protein synthesis in tendon tissue.
- •Former/current use of anabolic steroids or growth hormone.
- •Known rheumatoid disease or diabetes.
- •Former participation in trials using deuterated water and 15N tracers.
- •Treatment for patella tendinopathy within 3 months.
排除标准
- 未提供
结局指标
主要结局
Protein turnover in tendon tissue from patients with chronic tendinopathy compared to healthy controls
时间窗: 8 days
Fractional synthesis rate (FSR) measured in % pr. day in the trypsin-soluble and trypsin-insoluble fraction
次要结局
- Subjective pain in patella tendon(8 days)
- Leg press strength test(8 days)
- Anterior-posterior dimensions of patella tendon(8 days)
- Doppler flow in patella tendon(8 days)
- Single-leg decline squat test(1 day)
- Subjective measure of physical activity and function(1 day)
- One leg knee extension strength test(8 days)
- Tracer incorporation in isolated fractions of the tendon(8 days)
研究者
Ann Damgaard
Medical Doctor
Bispebjerg Hospital
研究点 (1)
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