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临床试验/NCT00624884
NCT00624884已完成不适用

Velocity Vector Imaging in Patients With Moderate-to-Severe Aortic Regurgitation

Florence Nightingale Hospital, Istanbul1 个研究点 分布在 1 个国家目标入组 50 人开始时间: 2008年3月最近更新:
适应症

试验速览

阶段
不适用
状态
已完成
发起方
入组人数
50
试验地点
1
主要终点
Velocity Vector Imaging derived segmental systolic peak Strain and Strain rates

研究概览

简要总结

Velocity Vector Imaging may provide reliable and detailed information on left ventricular segmental function in asymptomatic patients with moderate-to severe AR. This may help to identify subclinical myocardial dysfunction in order to operate early enough to prevent postoperative heart failure and restrict unnecessary early operation which could be associated with operative risks and mortality related to prosthetic valves.

详细描述

Chronic aortic regurgitation (AR) is a progressive process which causes both left ventricular volume and pressure overload. While the volume overload is associated with the degree of the aortic regurgitant volume, the pressure overload occurs as a result of systemic hypertension developed due to increased stroke volume. In early stages, excentric hypertrophy occurs aiming to compensate the volume overload in the left ventricle. Therefore , ejection fraction remains in normal range despite the increasing volume overload. Left ventricular dilatation and impairment in ejection fraction only occur in the end stages of the disease. Asymptomatic patients with chronic aortic regurgitation (AR) have a good prognosis in the presence of preserved systolic function. Therefore it is a challenge to identify patients with subclinical left ventricular (LV) dysfunction. Velocity vector imaging (VVI) is a new echocardiographic method based on two dimensional gray scale imaging, which is angle independent and can provide more accurate data about cardiac function.

研究设计

研究类型
Observational
观察模型
Case Control
时间视角
Prospective

入排标准

年龄范围
18 Years 至 75 Years(Adult, Older Adult)
性别
All
接受健康志愿者

入选标准

  • Moderate-to-severe aortic regurgitation identified by Standard echocardiography.
  • Chronic isolated aortic regurgitation
  • Being asymptomatic ( Class 1 according to NYHA)
  • Sinusal rhythm

排除标准

  • Ejection fraction < 50%
  • Mitral valve disease accompanied to aortic regurgitation (patients with over mild degree of mitral regurgitation and stenosis
  • Aortic stenosis
  • Previous myocardial infarction, or the patients with >50% coronary occlusion in any of the coronary arteries.
  • Cardiomyopathies
  • AV conduction disorders
  • Chronic renal or hepatic insufficiency
  • Malignities

结局指标

主要结局

Velocity Vector Imaging derived segmental systolic peak Strain and Strain rates

时间窗: April 2008

次要结局

未报告次要终点

研究者

发起方
Florence Nightingale Hospital, Istanbul
申办方类型
Other

研究点 (1)

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