Structural and Metabolic Determinants of Sarcopenia and the Efficacy of Concentric vs. Eccentric Exercise Training: a Novel Temporospatial Approach
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 60
- 试验地点
- 2
- 主要终点
- Muscle protein synthesis
研究概览
简要总结
The first goal of this study is the follow young and older people over a period of 8 weeks to define the processes responsible for loss of muscle length and width in age-related muscle wasting (sarcopenia) and allow us to look at age-related differences in tendon. Secondly, we will assess two different exercise interventions for reversing human sarcopenia; one which involves shortening of the muscle and the other which involves lengthening, whilst also studying why these exercises work the way they do. This project will have significant implications for our understanding of the control of skeletal muscle and tendon size in humans, particularly in relation to sarcopenia and the surrounding health issues.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Prevention
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 75 Years（Adult, Older Adult）
- 性别
- Male
- 接受健康志愿者
- 是
入选标准
- •Healthy male volunteers
- •Body mass index 18-30 kg/m2
- •Aged 18-35 and 65-75 years
排除标准
- •Participation in a formal exercise regime,
- •A BMI < 18 or > 30 kg/m2,
- •Active cardiovascular disease,
- •Taking beta-adrenergic blocking agents, statins or non-steroidal anti-inflammatory drugs,
- •Cerebrovascular disease,
- •Respiratory disease,
- •Metabolic disease,
- •Active inflammatory bowel or renal disease,
- •Malignancy,
- •Recent steroid treatment (within 6 months) or hormone replacement therapy,
- •Clotting dysfunction,
- •Musculoskeletal or neurological disorders,
- •Family history of early (<55y) death from cardiovascular disease
研究组 & 干预措施
Old Control
Older individuals (65-75 y) with no exercise intervention
Old Concentric
Older individuals (65-75 y) studied before and after 8 weeks concentric exercise training
干预措施: Concentric Exercise Training (Behavioral)
Old Eccentric
Older individuals (65-75 y) studied before and after 8 weeks eccentric exercise training
干预措施: Eccentric Exercise Training (Behavioral)
Young Control
Young individuals (18-30 y) with no exercise intervention
Young Concentric
Young individuals (18-30 y) studied before and after 8 weeks concentric exercise training
干预措施: Concentric Exercise Training (Behavioral)
Young Eccentric
Young individuals (18-30 y) studied before and after 8 weeks eccentric exercise training
干预措施: Eccentric Exercise Training (Behavioral)
结局指标
主要结局
Muscle protein synthesis
时间窗: 0 - 8 weeks
Comparison of muscle protein synthesis using D2O in young and older individuals and in response to 8 weeks concentric or eccentric exercise training
次要结局
- Tendon protein synthesis(0 - 8 weeks)