临床试验/NCT07461350

NCT07461350Enrolling By Invitation不适用

Stimulant and Polysubstance Use, Inflammation, and Sex Effects on Myocardial Disease in HIV (SPISE)

University of California, San Francisco4 个研究点分布在 1 个国家目标入组 400 人开始时间: 2026年8月5日最近更新: 2026年8月11日

适应症

试验速览

阶段: 不适用
状态: Enrolling By Invitation
发起方: University of California, San Francisco
入组人数: 400
试验地点: 4
主要终点: Cardiac MRI

研究概览研究设计入排标准研究组 & 干预措施结局指标研究者研究点记录与标识符相似试验

研究概览

简要总结

This observational research study is studying how substance use impacts scarring and inflammation of the heart. This study involves one study visit for a cardiac MRI.

研究设计

研究类型: Observational
观察模型: Cohort
时间视角: Prospective

入排标准

年龄范围: 30 Years 至 —（Adult, Older Adult）
性别: All
接受健康志愿者: 否

入选标准

•- Participants with and without HIV enrolled in the MACS/WIHS Combined Cohort Study (MWCCS) Atlanta, Baltimore, Bronx, and San Francisco study sites

排除标准

•Standard contraindications to MRI
•claustrophobia,
•metal implants,
•large body size (weight >350 lbs or abdominal sagittal diameter >70 cm),
•pregnancy)
•Gadolinium risk
•severe or uncontrolled asthma,
•visit day eGFR<45 ml/min/1.73 m2;
•poor venous access
•pregnancy or lactation

研究组 & 干预措施

No Stimulant use

Never used stimulants (amphetamines, cocaine, etc.)

Current Stimulant Use

Used stimulants (amphetamines, cocaine, etc.) in past year

Past Stimulant Use

Previously used stimulants (amphetamines, cocaine, etc.) but not in the last 12 months

结局指标

主要结局

Cardiac MRI

时间窗: Visit 1, up to 2 hours

CMR assessments to provide detailed myocardial characterization (e.g. diffuse inflammation (nT1), myocardial fibrosis (ECV), and myocardial scar assessed using LGE)

次要结局

未报告次要终点

研究者

发起方

University of California, San Francisco

申办方类型

Other

责任方

Sponsor

研究点 (4)

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