The Effect of Acute Time-Restricted Eating on Energy Intake, Subjective Appetite and Glycaemic Control in Young Healthy Males
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 18
- 试验地点
- 2
- 主要终点
- Glycaemic Control
研究概览
简要总结
This study compared the metabolic response to three different eating windows (morning fast,12pm-8pm; evening fast, 8am-4pm; control, 8am-8pm).
详细描述
Humans have evolved as a diurnal species, internally governed by the circadian system, which dictates our hormone regulation. 'Chrononutrition' is a sub-discipline which combines food timing with circadian physiology. The most popular method of time-restricted feeding in the UK is to skip breakfast. However, data from several meta-analysis have shown that skipping breakfast is associated with weight gain and insulin resistance, likely due to eating later into the evening/night and therefore, out of sync with our circadian rhythm. Recent research has shown that skipping dinner (evening fasting) has improved markers of cardio-metabolic health in clinical populations, although these are typically from longer-term studies. Despite these promising findings, it is not yet known whether these findings are population specific.
Therefore, the investigators are interested in examining the metabolic response pre and post-intervention to see whether these promising findings can translate into a healthy population. Furthermore, the investigators will be monitoring subjective appetite, energy intake, and expenditure to assess whether there is any short-term adaptation to a specific feeding window.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Prevention
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 30 Years(Adult)
- 性别
- Male
- 接受健康志愿者
- 是
入选标准
- •recreationally active
- •non-smokers
- •non-dieting
- •weight stable (self-reported for >6 months)
- •were not consuming any medication known to affect appetite or physical activity
排除标准
- •>10 hours per week physical activity
- •Have dieted within the past 6 months
- •Excessive alcohol consumption (>14 units/week)
- •Use of medication or supplements that may affect hormone concentrations.
结局指标
主要结局
Glycaemic Control
时间窗: 0 hour (Pre breakfast), 1 hour, 2 hour, 3.5 hour
A metabolic assessment lasting 3.5 hours will take place following a standardised, laboratory-based meal. The investigators will be taking periodic capillary and venous blood samples to measure post-prandial glucose and insulin, which together comprise 'glycaemic control'.
次要结局
- Energy Intake(3.5 hour following breakfast)
- Fat Oxidation(0 hour (pre breakfast), 1 hour, 2 hour, 3 hour)
- Energy expenditure(Activity recorded across day 1 standardisation and day 2 (lab visit and post lab visit))
- Visual analogue scale for subjective ratings of appetite(0 hour (pre-breakfast), 1 hour, 2 hour, 3 hour, 4 hour (post breakfast during lab visit))
- PYY (Appetite hormone)(0 hour (pre-breakfast), 1 hour, 2 hour, and 3 hour post breakfast)
- Carbohydrate Oxidation(0 hour (pre breakfast), 1 hour, 2 hour, 3 hour post breakfast)
- Acylated Ghrelin (Appetite hormone)(0 hour (pre breakfast), 1 hour, 2 hour, and 3 hour post breakfast)
研究者
William Mode
Principle Investigator
Nottingham Trent University
