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临床试验/NCT05309798
NCT05309798已完成不适用

The Effect of Acute Time-Restricted Eating on Energy Intake, Subjective Appetite and Glycaemic Control in Young Healthy Males

Nottingham Trent University2 个研究点 分布在 1 个国家目标入组 18 人开始时间: 2019年1月14日最近更新:
适应症

试验速览

阶段
不适用
状态
已完成
入组人数
18
试验地点
2
主要终点
Glycaemic Control

研究概览

简要总结

This study compared the metabolic response to three different eating windows (morning fast,12pm-8pm; evening fast, 8am-4pm; control, 8am-8pm).

详细描述

Humans have evolved as a diurnal species, internally governed by the circadian system, which dictates our hormone regulation. 'Chrononutrition' is a sub-discipline which combines food timing with circadian physiology. The most popular method of time-restricted feeding in the UK is to skip breakfast. However, data from several meta-analysis have shown that skipping breakfast is associated with weight gain and insulin resistance, likely due to eating later into the evening/night and therefore, out of sync with our circadian rhythm. Recent research has shown that skipping dinner (evening fasting) has improved markers of cardio-metabolic health in clinical populations, although these are typically from longer-term studies. Despite these promising findings, it is not yet known whether these findings are population specific.

Therefore, the investigators are interested in examining the metabolic response pre and post-intervention to see whether these promising findings can translate into a healthy population. Furthermore, the investigators will be monitoring subjective appetite, energy intake, and expenditure to assess whether there is any short-term adaptation to a specific feeding window.

研究设计

研究类型
Interventional
分配方式
Randomized
干预模型
Crossover
主要目的
Prevention
盲法
None

入排标准

年龄范围
18 Years 至 30 Years(Adult)
性别
Male
接受健康志愿者

入选标准

  • recreationally active
  • non-smokers
  • non-dieting
  • weight stable (self-reported for >6 months)
  • were not consuming any medication known to affect appetite or physical activity

排除标准

  • >10 hours per week physical activity
  • Have dieted within the past 6 months
  • Excessive alcohol consumption (>14 units/week)
  • Use of medication or supplements that may affect hormone concentrations.

结局指标

主要结局

Glycaemic Control

时间窗: 0 hour (Pre breakfast), 1 hour, 2 hour, 3.5 hour

A metabolic assessment lasting 3.5 hours will take place following a standardised, laboratory-based meal. The investigators will be taking periodic capillary and venous blood samples to measure post-prandial glucose and insulin, which together comprise 'glycaemic control'.

次要结局

  • Energy Intake(3.5 hour following breakfast)
  • Fat Oxidation(0 hour (pre breakfast), 1 hour, 2 hour, 3 hour)
  • Energy expenditure(Activity recorded across day 1 standardisation and day 2 (lab visit and post lab visit))
  • Visual analogue scale for subjective ratings of appetite(0 hour (pre-breakfast), 1 hour, 2 hour, 3 hour, 4 hour (post breakfast during lab visit))
  • PYY (Appetite hormone)(0 hour (pre-breakfast), 1 hour, 2 hour, and 3 hour post breakfast)
  • Carbohydrate Oxidation(0 hour (pre breakfast), 1 hour, 2 hour, 3 hour post breakfast)
  • Acylated Ghrelin (Appetite hormone)(0 hour (pre breakfast), 1 hour, 2 hour, and 3 hour post breakfast)

研究者

申办方类型
Other
责任方
Principal Investigator
主要研究者

William Mode

Principle Investigator

Nottingham Trent University

研究点 (2)

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