Molecular Spectroscopy in Identification and Assessment of Ovarian Cancer
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 160
- 试验地点
- 1
- 主要终点
- Ascertain the diagnostic performance of vibrational spectroscopy for detection of Ovarian Cancer
研究概览
简要总结
Ovarian cancer is the eighth most common cause of cancer death in the world. Advanced stage at diagnosis is associated with lower survival rates, thus early detection appears to have an important role.
Raman Spectroscopy is a non-invasive technique that uses the interaction of light to identify the composition of the sample tested.
The aim of the project is to explore the use of spectroscopic techniques in the detection of ovarian cancer. There are two different assessments within the project:
- Identify ovarian cancer in blood - Raman spectroscopic analysis will be performed on blood plasma taken from patients with suspected ovarian cancer.
- Detect active cancer within post chemotherapy fibrotic tissue - Ex vivo Raman spectroscopic analysis of peritoneal, omental or ovarian tissues collected from patients undergoing surgical treatment for ovarian cancer.
The results of the spectroscopy will be correlated to clinical outcome and histological diagnosis respectively.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Only
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- Female
- 接受健康志愿者
- 是
入选标准
- •Symptoms suggestive of ovarian cancer
- •Patients undergoing treatment of Ovarian Cancer
排除标准
- •Less than 18 years of age
- •Unable to consent to the study due to communication difficulties
- •Unable to consent to the study due to lack of capacity
结局指标
主要结局
Ascertain the diagnostic performance of vibrational spectroscopy for detection of Ovarian Cancer
时间窗: 2 years
Biomarkers for ovarian cancer will be identified by analysing Raman spectral data of plasma samples taken from patient with ovarian cancer symptoms. Clinical outcome of cancer/no cancer will be used to correlate the results.
Ascertain the discriminatory ability of vibrational spectroscopy to differentiate between normal, fibrotic and cancerous tissue
时间窗: 2 years
Samples taken from post chemotherapy patients will be analysed to identify the spectral signature of ovarian cancer in chemotherapy exposed tissue.
次要结局
- Performance of vibrational spectroscopy in recurrence prediction(2 years)
- Performance of vibrational spectroscopy in chemotherapy response prediction(2 years)