The Effect of SPU on Hormonal and Cardiometabolic Factors
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 60
- 试验地点
- 1
- 主要终点
- Total cholesterol
研究概览
简要总结
The study examines the immediate effect of soleus pushup exercise on cardiometabolic and hormonal functions among hypothyroid patients.
详细描述
The primary characteristic of hypothyroidism is sluggish metabolism, which is usually associated with abnormal weight gain, lethargy, constipation, heavy menstrual bleeding, hair loss, cold intolerance, and bradycardia. Importantly, these symptoms have been linked to reduced glucose tolerance and insulin sensitivity though glucose turnover and plasma insulin concentration are elevated. These metabolic changes result in hyperlipidemia, hypercholesterolemia, and elevated insulin resistance, and circulatory low-density lipoprotein cholesterol and total triglyceride levels. Hormonal replacement therapy, the primary treatment for hypothyroidism, partially restores the thyroid function and tappers down the disease symptoms. However, the therapy is associated a plethora of side effects, thus alternative therapies are warranted.
The effect of exercise on thyroid function and metabolism among patients with hypothyroidism is still equivocal. The soleus pushup exercise, a localized exercise that stimulates mainly oxidative metabolism, has been shown to have promising, favorable changes in systemic metabolism. Therefore, the current study compares metabolic and hormonal responses to soleus pushup exercise in patients with hypothyroidism versus healthy controls.
Patients diagnosed with hypothyroidism are recruited to participate in the study. Cardiovascular and circulatory, metabolic, and hormonal measures are determined from blood samples obtained from the patients. Age- and gender-matched healthy individuals are recruited to serve as controls.
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Individuals aged 18-80,
- •Patients diagnosed with hypothyroidism
- •Patients diagnosed with hyperthyroidism
- •Patients diagnosed with hypertension
- •Patients diagnosed with diabetes mellitus
- •Prediabetics
- •Individuals who usually avoid regular physical/muscular activities involving lower limbs
- •Age/gender matched apparently healthy individuals
排除标准
- •Patients diagnosed with orthopedic diseases
- •Patients diagnosed with cardiovascular diseases (other than hypertension)
- •Patients diagnosed with renal dysfunction
结局指标
主要结局
Total cholesterol
时间窗: 3 hours
Total cholesterol will be measured in blood and reported in mg/dL.
Triglycerides
时间窗: 3 hours
Triglycerides will be measured in blood and reported in mg/dL.
HDL-C
时间窗: 3 hours
High-density lipoprotein cholesterol will be measured in blood and reported in mg/dL.
LDL-C
时间窗: 3 hours
Low-density lipoprotein cholesterol will be calculated using the lipid profile and reported in mg/dL.
VLDL-C
时间窗: 3 hours
Very-low-density lipoprotein cholesterol will be calculated from triglycerides and reported in mg/dL.
Non-HDL cholesterol
时间窗: 3 hours
Non-HDL cholesterol will be calculated as total cholesterol minus HDL-C and reported in mg/dL.
Apolipoprotein A-I
时间窗: 3 hours
Apolipoprotein A-I will be measured in blood and reported in mg/dL.
Apolipoprotein B
时间窗: 3 hours
Apolipoprotein B will be measured in blood and reported in mg/dL.
Lipoprotein(a)
时间窗: 3 hours
Lipoprotein(a) will be measured in blood and reported in mg/dL or nmol/L, depending on the laboratory assay.
Fasting blood glucose
时间窗: 3 hours
Fasting blood glucose will be measured in blood and reported in mg/dL.
Random blood glucose
时间窗: 3 hours
Random blood glucose will be measured in blood and reported in mg/dL.
HbA1c
时间窗: 3 hours
Glycated hemoglobin will be measured in blood and reported as a percentage.
Insulin
时间窗: 3 hours
Insulin will be measured in blood and reported in µIU/mL or mIU/L, depending on the laboratory assay.
Glucagon
时间窗: 3 hours
Glucagon will be measured in blood and reported in pg/mL.
Catecholamines
时间窗: 3 hours
Catecholamines will be measured in blood and reported in pg/mL.
Thyroid-stimulating hormone
时间窗: 3 hours
Thyroid-stimulating hormone will be measured in blood and reported in mIU/L or µIU/mL, depending on the laboratory assay.
Triiodothyronine
时间窗: 3 hours
Triiodothyronine will be measured in blood and reported in ng/dL.
Thyroxine
时间窗: 3 hours
Thyroxine will be measured in blood and reported in µg/dL.
Brain-derived neurotrophic factor
时间窗: 3 hours
Brain-derived neurotrophic factor will be measured in blood and reported in pg/mL or ng/mL, depending on the laboratory assay.
Leptin
时间窗: 3 hours
Leptin will be measured in blood and reported in ng/mL.
Adiponectin
时间窗: 3 hours
Adiponectin will be measured in blood and reported in µg/mL.
Glucagon-like peptide
时间窗: 3 hours
Glucagon-like peptide will be measured in blood and reported in pmol/L or pg/mL, depending on the laboratory assay.
Heart rate
时间窗: 3 hours
Heart rate will be measured using the standard auscultatory method and reported in beats per minute.
Systolic blood pressure
时间窗: 3 hours
Systolic blood pressure will be measured using the standard auscultatory method and reported in mmHg.
Diastolic blood pressure
时间窗: 3 hours
Diastolic blood pressure will be measured using the standard auscultatory method and reported in mmHg.
Pulse pressure
时间窗: 3 hours
Pulse pressure will be calculated as systolic blood pressure minus diastolic blood pressure and reported in mmHg.
Rate-pressure product
时间窗: 3 hours
Rate-pressure product will be calculated as heart rate multiplied by systolic blood pressure and reported in bpm × mmHg.
Mean arterial pressure
时间窗: 3 hours
Mean arterial pressure will be calculated as diastolic blood pressure plus one-third of pulse pressure and reported in mmHg.
次要结局
未报告次要终点
研究者
Mahmoud Alomari
Professor
Jordan University of Science and Technology