"Exhaled Breath Condensate" in Allogeneic Stem Cell Recipients and Value in Follow-up
试验速览
- 阶段
- 不适用
- 入组人数
- 80
- 主要终点
- The pH level of exhaled breath condansate
研究概览
简要总结
The most effective treatment of hematologic malignancies and some benign hematological diseases is allogeneic stem cell transplantation therapy. Pulmonary complications can occur after allogeneic stem cell transplantation. And these complications effect mortality and morbidity in these patients. In this study we want to investigate the use of exhaled breath condensate (EBC) collection which is a simple and completely noninvasive method. By this way we hope to detect pulmonary complications early. EBC, has been implicated in the pathophysiology of inflammatory airway diseases such as cystic fibrosis, asthma, chronic obstructive pulmonary disease (COPD) and bronchiectasis. EBC, has not been investigated before in patients who underwent stem cell transplantation.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Only
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 75 Years(Adult, Older Adult)
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •hematologic malignancies or benign hematological diseases that allogeneic stem cell transplantation performed
排除标准
- •allogeneic stem cell transplantation patients with Asthma or COPD
结局指标
主要结局
The pH level of exhaled breath condansate
时间窗: 2 years
次要结局
- The nitrotyrosine and 8-isoprostane levels of exhaled breath condansate(2 years)
