跳至主要内容
临床试验/NCT02318316
NCT02318316Unknown不适用

"Exhaled Breath Condensate" in Allogeneic Stem Cell Recipients and Value in Follow-up

Gazi University0 个研究点目标入组 80 人开始时间: 2014年12月最近更新:
适应症

试验速览

阶段
不适用
入组人数
80
主要终点
The pH level of exhaled breath condansate

研究概览

简要总结

The most effective treatment of hematologic malignancies and some benign hematological diseases is allogeneic stem cell transplantation therapy. Pulmonary complications can occur after allogeneic stem cell transplantation. And these complications effect mortality and morbidity in these patients. In this study we want to investigate the use of exhaled breath condensate (EBC) collection which is a simple and completely noninvasive method. By this way we hope to detect pulmonary complications early. EBC, has been implicated in the pathophysiology of inflammatory airway diseases such as cystic fibrosis, asthma, chronic obstructive pulmonary disease (COPD) and bronchiectasis. EBC, has not been investigated before in patients who underwent stem cell transplantation.

研究设计

研究类型
Observational
观察模型
Case Only
时间视角
Prospective

入排标准

年龄范围
18 Years 至 75 Years(Adult, Older Adult)
性别
All
接受健康志愿者

入选标准

  • hematologic malignancies or benign hematological diseases that allogeneic stem cell transplantation performed

排除标准

  • allogeneic stem cell transplantation patients with Asthma or COPD

结局指标

主要结局

The pH level of exhaled breath condansate

时间窗: 2 years

次要结局

  • The nitrotyrosine and 8-isoprostane levels of exhaled breath condansate(2 years)

研究者

申办方类型
Other
责任方
Principal Investigator
主要研究者

Nilgün Yılmaz Demirci

MD

Gazi University

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