NCT06009016招募中不适用

Inflammation and Coagulation Factors in Cerebrospinal Fluid for Predicting Persistent Cerebral Edema After Subarachnoid Hemorrhage

Second Affiliated Hospital, School of Medicine, Zhejiang University1 个研究点分布在 1 个国家目标入组 80 人开始时间: 2022年8月1日最近更新: 2023年8月24日

适应症

试验速览

阶段: 不适用
状态: 招募中
发起方
入组人数: 80
试验地点: 1
主要终点: Cerebral edema after subarachnoid hemorrhage

研究概览研究设计入排标准结局指标研究者研究点记录与标识符相似试验

研究概览

简要总结

Explore the role of Inflammation and coagulation factors in cerebrospinal fluid for predicting persistent cerebral edema after subarachnoid hemorrhage

研究设计

研究类型: Observational
观察模型: Cohort
时间视角: Prospective

入排标准

年龄范围: 20 Years 至 80 Years（Adult, Older Adult）
性别: All
接受健康志愿者: 否

入选标准

•Subarachnoid hemorrhage patients admitted to our neurosurgery department with modified Fisher Scale 3-4, with a confirmed radiographic diagnosis.

排除标准

•Angiogram-negative patients, patients with a history of trauma or previous brain injury (stroke, hemorrhage, surgery et al. which left associated chronic changes on CT), arteriovenous malformation, radiological data lost, accompany with serious comorbidities before subarachnoid hemorrhage onset (such as coagulation defects, uncontrollable hypertension, and arrhythmia et.al.), initial radiological data performed more than 3 days after SAH onset

结局指标

主要结局

Cerebral edema after subarachnoid hemorrhage

时间窗: At 3 and 7days after SAH onset

Cerebral edema after subarachnoid hemorrhage will be determined by the SEBES score. SEBES 0-2 is mild edema; SEBES 3-4 is severe edema.

Outcome at 3 months after subarachnoid hemorrhage

时间窗: 3 months after subarachnoid hemorrhage

Outcome will be determined by the modified Rankin Score (mRS). mRS 0-2 is favorable outcome; mRS3-5 is poor outcome.

次要结局

未报告次要终点

研究者

发起方

Second Affiliated Hospital, School of Medicine, Zhejiang University

申办方类型

Other

责任方

Principal Investigator

主要研究者

Yuanjian Fang

Second Affiliated Hospital, School of Medicine, Zhejiang University

研究点 (1)

Loading locations...

相似试验

已完成

不适用

CSF/Serum Biomarkers in Predicting PND/Persistent Pain After CesareanChronic PainPerinatal Depression

NCT04271072Duke University81

已完成

不适用

Identification of Biomarkers in Spinocerebellar Ataxia 3Spinocerebellar Ataxia Type 3

NCT03885167University of Michigan22

已完成

不适用

Dysregulated CNS Inflammation After Acute Brain InjuryTraumatic Brain InjuryAneurysmal Subarachnoid Hemorrhage

NCT03287557University of Kentucky8

进行中（未招募）

不适用

Identification of Cellular and Molecular Mechanisms Involved in the Pathophysiology of Alcohol Use Disorder by Examination of Cerebrospinal FluidAlcohol Use Disorder

NCT06286449Vastra Gotaland Region50

尚未招募

2 期

Cerebrospinal Fluid Immune Microenvironment Mechanism in Anaplastic Lymphoma Kinase Positive Lung Cancer PatientsCarcinoma, Non-Small-Cell Lung

NCT06697990Tianjin Medical University Cancer Institute and Hospital12