Aberrant receptor expression in thyroid tissue: A role in the pathogenesis of multinodular goiter? A pilot study - Aberrant receptor expression in thyroid tissue

Academisch Medisch Centrum0 个研究点目标入组 15 人开始时间: 待定最近更新: 2024年5月6日

试验速览

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•* Informed consent form signed
•* Age 18 years and over
•* Multinodular goiter, confirmed with thyroid ultrasound
•* Subclinical hyperthyroidism, defined as TSH < 0.10 mE/l and free T4 within reference range [10.0 * 23.0 pmol/l]
•* T3 level within reference range, i.e. between 1.30 and 2.70 nmol/l

•* Current use of antithyroid drugs
•* Treatment with radioactive iodine in history
•* Pregnancy. This condition may lead to subtle enlargement of the thyroid gland, secondary to iodine deficiency. All premenopausal female participants will undergo a *-hCG-urine test before inclusion.
•* Born and raised in iodine deficient areas, defined as the green and dark green fields in Figure 3 (protocol, p 13) .
•* Any medication known to interfere with thyroid hormone metabolism or with the study medication, like amiodarone, beta blockers, neuroleptics, corticosteroids including inhalation steroids, antihistaminics
•* Any condition that the investigator feels would interfere with trial participation or evaluation of results

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