The Comparison of Changes of QTc, Tp-e Interval, and Tp-e/QT Ratio, Tp-e/QTc Ratio on the ECG During Living Donor Liver Transplantation Under Desflurane and Total Intravenous Anesthesia -Randomized Controlled Trial
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 120
- 试验地点
- 1
- 主要终点
- QTc interval
研究概览
简要总结
Prolonged corrected QT interval (QTc) has been observed in about half of patients with liver cirrhosis. Marked prolongation of QTc (ie, 500 msec) has been considered to be a risk factor for fatal ventricular arrhythmia, such as torsade de pointes,7,8 which has been reported in liver transplantation (LT) surgery. In a previous study, prolonged QTc interval ( 500 msec) was frequently observed throughout the procedure of LT, even among patients with baseline QTc 440 msec. Therefore, it is important to optimize electrolyte balance and hemodynamic status to reduce greater risk of perioperative arrhythmias.
The investigators hypothesized that the change of QTc interval might be differ according to method of general anesthesia (inhalation agent vs. intravenous agent).
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Other
- 盲法
- Triple (Participant, Investigator, Outcomes Assessor)
盲法说明
patients will be randomly allocated to 2 groups using computer-generated randomization method. Care provider will not be blinded to the group allocation, because anesthesiologists should be aware of the method of anesthesia.
入排标准
- 年龄范围
- 20 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •patients with liver cirrhosis who will undergo planned liver transplantation
排除标准
- •emergent liver transplantation
- •unstable angina
- •recent MI(Myocardial Infarction)
- •uncontrolled hypertension (diastolic BP > 110mmHg)
- •implantable cardiac defibrillator
- •severe obesity (BMI>30kg/m2)
- •allergy to propofol
研究组 & 干预措施
inhalation anesthesia (desflurane) group
Anesthesia is induced and maintained with desflurane and sufentanil
干预措施: inhalation (desflurane) group (Drug)
Total intravenous anesthesia (propofol) group
Anesthesia is induced and maintained with propofol and sufentanil
干预措施: total intravenous (propofol) anesthesia (Drug)
结局指标
主要结局
QTc interval
时间窗: 3 minutes after liver reperfusion
The investigator will assess the QTc interval 3 minutes after the reperfusion during liver transplantation.
次要结局
- QTc interval(at the end of the surgery)