A Prospective Study on Predictive Value of Non-Invasive Atherosclerotic Measurements in Elderly Chinese
试验速览
- 阶段
- 不适用
- 入组人数
- 1,290
- 试验地点
- 1
研究概览
简要总结
The purpose of this study is to determine whether non-invasive atherosclerotic measurements (baPWV, IMT, FMD, CACS, ABI) are valuable predictors for cardiovascular events in elderly. At inception, routine physical examination and non-invasive atherosclerotic measurements will conducted on all participants. Then they will be followed prospectively for at least 2 years. All cardiovascular and other health events will be recorded.
详细描述
Cardiovascular disease is the most common cause of morbidity and mortality in the world, especially in elderly. Conventional risk factors are widely used in clinical practice, but it is inadequate and inaccurate due to no direct evaluation of artery. However, invasive method, it is difficult to be applied in atherosclerosis screening and only used in advanced institutions, is expensive and unacceptable. We are trying to assess the value of noninvasive measurements in predicting cardiovascular events.
Five invasive methods will be applied in the study, including
- brachial-ankle Pulse Wave Velocity(baPWV)
- Carotid Intimal-Medial Thickness(CIMT)
- Flow Mediated Dilation(FMD)
- Ankle-Brachial Index(ABI)
- Coronary Artery Calcification Score(CACS)
These indices represent not only different phase of atherosclerosis, but also various sections and arterial layers.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 60 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Chinese, age>=60, no gender restriction.
- •To be able to apply the measurement mentioned above.
- •Medical history are maintained precisely.
- •Tianjin Medical University General Hospital is the participants' designated hospital by national health authority.
排除标准
- •Systemic inflammation.
- •Malignant tumor
- •Chronic lung disease
- •Liver disease
- •Aortic aneurysm