NCT01580982招募中不适用
Molecular Analysis of Oncogenes and Resistance Mechanisms in Lung and Other Thoracic Cancers
适应症
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 500
- 试验地点
- 1
- 主要终点
- To identify baseline and treatment-related somatic changes in the tumor tissue from patients with lung and other thoracic cancers.
研究概览
简要总结
The mechanisms of sensitivity and resistance to oncogene-targeted therapy can be determined from tumor tissue or tumor cell lines derived from available archival samples and/or from standard-of-care re-biopsy upon suspected tumor progression.
详细描述
To identify baseline and treatment-related somatic changes in the tumor tissue from patients with lung and other thoracic cancers. To estimate the proportion of patients that subsequent therapy is altered based on the information acquired from such biopsies.
研究设计
- 研究类型
- Observational
- 观察模型
- Other
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 85 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients undergoing investigation or treatment for thoracic cancers with oncogene-targeted therapies
- •Aged 18 years or older
- •Either a) have suspected tumor progression or other condition that dictates a standard-of-care palliative, therapeutic, or diagnostic intervention including but not limited to procedures such as bronchoscopic biopsy, computed tomography (CT) or ultra-sound (US)-guided biopsy, thoracentesis, video assisted thoracoscopic (VATS) pleurodesis, lobectomy, adrenalectomy or pleural catheter placement, providing tumor specimen appropriate molecular analysis or b) have previously had biopsy/surgical intervention with tumor tissue at University of Colorado or an outside institution available for medullar analysis.
- •Patients must have the ability to understand and willingness to sign an informed consent document.
排除标准
- 未提供
结局指标
主要结局
To identify baseline and treatment-related somatic changes in the tumor tissue from patients with lung and other thoracic cancers.
时间窗: To be determined upon funding
次要结局
- To estimate the proportion of patients that subsequent therapy is altered based on the information acquired from such biopsies(To be determined upon funding)
研究者
研究点 (1)
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