Molecular Analysis of Oncogenes and Resistance Mechanisms in Lung and Other Thoracic Cancers

University of Colorado, Denver1 个研究点分布在 1 个国家目标入组 500 人2012年1月23日

适应症Lung Neoplasms

概览

阶段: 不适用
干预措施: 未指定
疾病 / 适应症: Lung Neoplasms
发起方: University of Colorado, Denver
入组人数: 500
试验地点: 1
主要终点: To identify baseline and treatment-related somatic changes in the tumor tissue from patients with lung and other thoracic cancers.
状态: 招募中
最后更新: 2个月前

概览研究者入排标准结局指标研究点相似试验

概览

简要总结

The mechanisms of sensitivity and resistance to oncogene-targeted therapy can be determined from tumor tissue or tumor cell lines derived from available archival samples and/or from standard-of-care re-biopsy upon suspected tumor progression.

详细描述

To identify baseline and treatment-related somatic changes in the tumor tissue from patients with lung and other thoracic cancers. To estimate the proportion of patients that subsequent therapy is altered based on the information acquired from such biopsies.

注册库

clinicaltrials.gov

开始日期

2012年1月23日

结束日期

2029年1月30日

最后更新

2个月前

研究类型

Observational

性别

All

研究者

发起方

University of Colorado, Denver

责任方

Sponsor

入排标准

入选标准

•Patients undergoing investigation or treatment for thoracic cancers with oncogene-targeted therapies
•Aged 18 years or older
•Either a) have suspected tumor progression or other condition that dictates a standard-of-care palliative, therapeutic, or diagnostic intervention including but not limited to procedures such as bronchoscopic biopsy, computed tomography (CT) or ultra-sound (US)-guided biopsy, thoracentesis, video assisted thoracoscopic (VATS) pleurodesis, lobectomy, adrenalectomy or pleural catheter placement, providing tumor specimen appropriate molecular analysis or b) have previously had biopsy/surgical intervention with tumor tissue at University of Colorado or an outside institution available for medullar analysis.
•Patients must have the ability to understand and willingness to sign an informed consent document.

排除标准

未提供

结局指标

主要结局

To identify baseline and treatment-related somatic changes in the tumor tissue from patients with lung and other thoracic cancers.

时间窗: To be determined upon funding

次要结局

To estimate the proportion of patients that subsequent therapy is altered based on the information acquired from such biopsies(To be determined upon funding)