NCT01684293已完成不适用
Occupational Therapy-Based Cognitive Rehabilitation of Cocaine Abusers: A Pilot Study
适应症
干预措施
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 50
- 试验地点
- 1
- 主要终点
- Change in cognitive impairment
研究概览
简要总结
This study integrates a model of occupational-therapy based cognitive rehabilitation as part of a comprehensive treatment plan for cocaine abusers. We hypothesize that cognitive impairment and quality of life would improve and that cocaine use would decrease in those participants receiving occupational-therapy based cognitive rehabilitation.
详细描述
occupational-therapy based cognitive rehabilitation as part of a comprehensive treatment plan for cocaine abusers
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Single (Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 65 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Primary cocaine use disorder (based on DSM-5 criteria) and in at least 3 months of remission
- •At least mild cognitive impairment, defined as = or > 1.5 standard deviations impairment on any 2 performance-based neurocognitive measures
- •Needing to change quality of life, defined as self-identifying at least 2 life areas as needing to change on the Drug User Quality of Life Scale
- •A Veteran at the San Francisco Veterans Affairs Medical Center
- •Currently receiving weekly drug counseling (individual or group; at least 1 hour/week) through an outpatient substance use disorder treatment program
排除标准
- •Inability to speak, read, write, and understand English
- •Inadequate hearing or vision
- •Concurrent substance use disorder (except tobacco or caffeine) not in at least 3 months of remission
- •A psychiatric disorder that will interfere with study participation or will make participation hazardous (e.g., psychosis, suicidal or homicidal ideations, severe anxiety)
- •A depressive disorder classified as severe, defined as a Beck Depression Inventory-II score >29
- •Current diagnosis of a bipolar disorder needing acute inpatient psychiatric hospitalization
- •Currently symptomatic from attention-deficit/hyperactivity disorder (DSM-5 criteria)
- •Any learning disorder, any type of dementia, any type of delirium, or an amnestic disorder due to any general medical condition
- •Wechsler Test of Adult Reading standard score <70
- •Mini-Mental State Examination score <24
- •Current use of scheduled (i.e., prescribed) regular (i.e., daily) psychotropics or other medicines with a high likelihood of sedation & cognitive impairment (e.g., benzodiazepines, clozapine, anticholinergics)
- •Currently prescribed stimulants (e.g., methylphenidate) or cognitive enhancers (e.g., donepezil, memantine)
- •Active medical illnesses - uncontrolled diabetes, uncontrolled hypertension, uncontrolled thyroid dysfunction, or uncontrolled B12/folate deficiency; central nervous system illness with potential cognitive aspects (Parkinson's, or Huntington's dementia); Cirrhosis with complications (e.g., ascites, encephalopathy, jaundice, gastrointestinal bleeding); Needing acute medical hospitalization from HIV sequelae, such as HIV-related opportunistic infection
- •Any history of any type of stroke or brain hemorrhage
- •Any history of traumatic brain injury, intracranial pathology (e.g., tumor), or brain surgery
- •Currently on probation or parole
- •Concurrent participation in another study that medically/administratively interferes with this study
研究组 & 干预措施
Psychoeducation/games
Placebo Comparator
Psychoeducation/games
干预措施: Psychoeducation/games (Behavioral)
Cognitive Rehabilitation
Experimental
Occupational therapy-based cognitive rehabilitation
干预措施: Occupational therapy-based cognitive rehabilitation (Behavioral)
结局指标
主要结局
Change in cognitive impairment
时间窗: baseline through 6 months
Global Deficit Score, range 0 (no impairment) to 5 (severe impairment)
次要结局
未报告次要终点
研究者
研究点 (1)
Loading locations...
相似试验
Unknown
不适用
eHealth Interventions for Breast Cancer Cognitive ImpairmentCognitive DysfunctionBreast CancerNCT06103318Institut Català d'Oncologia176
尚未招募
不适用
Occupational therapy intervention for cognitive and functional training in patients with brain tumorCTRI/2022/04/041795Tata Memorial Hospital
Unknown
不适用
HIV Medication Adherence in Underserved PopulationsHuman Immunodeficiency VirusAcquired Immunodeficiency SyndromeNCT02392884Cedars-Sinai Medical Center60
已完成
4 期
The Study of Cognitive Rehabilitation Effectiveness for Mild Traumatic Brain InjuryTraumatic Brain Injury With Brief Loss of ConsciousnessTraumatic Brain Injury With No Loss of ConsciousnessNCT01339806Brooke Army Medical Center143
Enrolling By Invitation
不适用
Combined Activity and Cognitive Intervention for ICU SurvivorsPost Intensive Care SyndromeLoss of Muscle MassCognitive FunctionARDS: Acute Respiratory Distress SyndromeLoss of Muscle StrengthDeliriumNCT06117761The University of Hong Kong60