Comparison of Red Cell Distribution Width Versus Presepsin (Soluble CD14) for Prognosis Assessment in Sepsis Patients Admitted to the Intensive Care Unit
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 200
- 试验地点
- 1
- 主要终点
- Mortality during intensive care unit stay
研究概览
简要总结
Presepsin (soluble CD14 subtype) is a novel marker with growing body of evidence supporting its accuracy and value for the diagnosis of sepsis. Patients with sepsis showed higher Prsepsin levels compared to those with SIRS. In addition the increase in Prsepsin levels correlates well with sepsis severity. Red cell distribution width variations are increased in a variety of medical conditions such as congestive heart failure, acute myocardial infarction, pulmonary embolism, pneumonia, critical illness, and cardiac arrest , and is a predictor of mortality in the general population. we aim to compare between Presepsin (soluble CD14) and RDW as prognostic markers in critically-ill patients with sepsis.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 18 Years 至 65 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Male or female aged 18 65 years.
- •Appropriate clinical data to enable classification into sepsis or SIRS according to Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3).
- •Written informed consent by the patient or guardian
排除标准
- •No informed consent
- •Renal failure
- •Liver failure
- •Hematologic diseases
- •Neutropenia
- •Malignancy
- •Chemotherapy during the previous 90 days.
- •Patients using antibiotics at presentation
结局指标
主要结局
Mortality during intensive care unit stay
时间窗: 28 days
次要结局
- Need for readmission to ICU(assessed up to 3 months)
- Ventilatory support duration(assessed up to 3 months)
- Number of participants who need inotropic or vasopressor support(assessed up to 3 months)
- Length of ICU stay(assessed up to 3 months)
- Number of participants who need renal replacement therapy(assessed up to 3 months)
- Transfusion requirements (blood and blood products)(assessed up to 3 months)
研究者
Ahmed Elsayed
Principal Investigator
Ain Shams University