Adaptive, multicenter, randomized, controlled, open trial of the use of early prone positioning in conscious patients with severe COVID-19 without invasive ventilatory support, to prevent invasive mechanical ventilation and death. - Adaptive, multicenter, randomized, controlled, open trial of the use of early prone positioning in conscious patients with severe COVID-19 without invasive ventilatory support, to prevent invasive mechanical ventilation and death (APPearl)

Mexican Secretariat of Health Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran. Intensive Care Unit0 个研究点目标入组 384 人开始时间: 2021年10月27日最近更新: 2023年10月17日

试验速览

阶段: 未知
状态: 招募中
发起方
入组人数: 384

研究概览入排标准研究者记录与标识符相似试验

研究概览

简要总结

暂无简介。

研究设计

研究类型: Interventional

入排标准

年龄范围: 18years-old 至 ot applicable（—）
性别: All

入选标准

未提供

排除标准

•1.Patients in palliative care 2.Patients with imminent orotracheal intubation according to refractory hypoxemia with acute respiratory distress syndrome (ARDS), acute respiratory acidosis (pH < 7.15, PaCO2 >45 mmHg) with ARDS, requirement of airway protection. 3.Patients with unsolved shock (reanimation phase or norepinephrine dose greater than or equal to 0.15 mcg/kg/min). 4.Unstable arrythmias (bradycardia o tachycardia). 5.Mental agitation or altered mental state (Glasgow Comma Scale <10 points) that would impede cooperation to self-prone. 6.Instability of the pelvis, vertebral column, or femur due to recent surgery or trauma. 7.Anatomical alterations that limit the adoption of prone position (severe kyphoscoliosis, muscle contracture, or other). 8.Abdominal surgery in the last 15 days. 9.Thoracic lesion or surgery in the last 15 days. 10.Pregnancy 11.Intracranial hypertension 12.Deep vein thrombosis in the last 2 days. 13.Heart pacemaker surgery in the last 2 days. 14.Chest tube with air leak 15.Recent facial trauma or surgery 16.Morbid obesity (BMI >40 kg/m2) 17.Pressure lesions or ulcers

研究者

发起方

Mexican Secretariat of Health Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran. Intensive Care Unit

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