Open-lung Ventilatory Approach With Positive End-expiratory Pressure Titrated to Lowest Driving Pressure in Cardiac Surgery Patients
试验速览
- 阶段
- 不适用
- 发起方
- 入组人数
- 60
- 试验地点
- 2
- 主要终点
- driving pressure
研究概览
简要总结
This study aims to compared the effects in driving pressure of an open-lung strategy with a positive end-expiratory pressure (PEEP) titrated to best driving pressure (DP) after a RM versus the recommended protective PEEP of 5 cmH2O without a recruitment manuever in non-obese patients undergoing cardiac surgery.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Single (Participant)
入排标准
- 年龄范围
- 18 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Non-obese patients scheduled for cardiac surgery (CABG and valve replacement)
排除标准
- •i) age <18yr or >80yr, ii) pregnancy or breast-feeding status, and iii) patients with previous known respiratory disease, iv) Body mass index >35 kg/m2, v) emergency surgery and vi) hemodynamic instability at entry (need of vasopressors or ionotropes at entry or a ventricular assist device.
研究组 & 干预措施
DP-PEEP
recruitment maneuver + individualized PEEP
干预措施: DP-PEEP (Procedure)
RM-5
recruitment maneuver + fixed standard PEEP
干预措施: RM-5 (Procedure)
结局指标
主要结局
driving pressure
时间窗: intraoperative
The driving pressure is a physiological ventilatory parameter measured as platteau pressure minus PEEP. This parameter may be associated with postoperative pulmonary complications
次要结局
- Postoperative pulmonary complications(72 first postoperative hours)
研究者
Carlos Ferrando
Principal investigador
Fundación para la Investigación del Hospital Clínico de Valencia