Prevention of Alcohol Intolerance
试验速览
- 阶段
- 2 期
- 状态
- 已完成
- 入组人数
- 30
- 试验地点
- 1
- 主要终点
- Mean Area of Skin Erythema (Skin Redness)
研究概览
简要总结
This study is designed to determine whether Asians who are especially sensitive to alcohol exposure can be protected by boosting their activities of an alcohol disposing enzyme. This will be accomplished by administering broccoli sprouts that are rich in an agent that increases protective enzyme activity. The test system involves applying alcohol patches to the skin and measuring skin redness.
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Single Group
- 主要目的
- Prevention
- 盲法
- Double (Participant, Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 70 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •18-70 years old,
- •sensitive to alcohol on the skin, Japanese
排除标准
- •recent skin abnormalities /tanning
研究组 & 干预措施
Broccoli Sprout Extract
Each subject will act as his/her own control and receive both treatment and placebo on adjacent skin regions.
干预措施: Broccoli Sprout Extract (Drug)
Placebo
Each subject will act as his/her own control and receive both treatment and placebo on adjacent skin regions.
干预措施: Placebo (Drug)
结局指标
主要结局
Mean Area of Skin Erythema (Skin Redness)
时间窗: mean up to 2 hours
For three days in a row, volunteers will receive skin treatments with broccoli sprout extract. On day four, their skin will be measured for a baseline skin color reading. Immediately following this reading, the treated areas of the skin will be challenged with 70 percent alcohol and the redness of the skin will again be measured every 30 minutes for the following two hours for skin color changes. The values were collected every 30 minutes after the alcohol skin challenge for 2 hours and were averaged. Mean and 95% Confidence Interval are reported.
次要结局
未报告次要终点