Host-pathogen Interactions in Meningococcal Disease: Finding the Key That Fits the Lock
试验速览
- 阶段
- 不适用
- 状态
- 撤回
- 试验地点
- 1
- 主要终点
- informed consent obtained for all culture-confirmed IMD to sequence their genome.
研究概览
简要总结
At any time, around 10% of people carry meningococcal bacteria in the nose and throat, which can cause meningitis, blood poisoning and other serious illnesses. Most people carry these bacteria and never become ill, yet a very small proportion go on to develop these illnesses which can result in life long disabilities or death. The mechanism by which this happens is poorly understood and has been studied in various ways, usually focussing on the bacteria or on the individual, but none has given a definitive answer. This study will be the first of its kind and will assess the interaction between the host and the bacteria at the genetic level, through genetic mapping, helping us to understand what makes some people susceptible to this infection.
详细描述
At any time, around 10% of people carry meningococcal bacteria in the nose and throat, which can cause meningitis, blood poisoning and other serious illnesses. Most people carry these bacteria and never become ill, yet a very small proportion go on to develop these illnesses which can result in life long disabilities or death. The mechanism by which this happens is poorly understood and has been studied in various ways, usually focussing on the bacteria or on the individual, but none has given a definitive answer. This study will be the first of its kind and will assess the interaction between the host and the bacteria at the genetic level, through genetic mapping, helping us to understand what makes some people susceptible to this infection.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Other
入排标准
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •any individual with culture-confirmed IMD in England from 01 September 2015 to 31 August 2019
- •written informed consent from the individual, the parent (for children aged <16 years) or next-of-kin (for non-survivors)
排除标准
- •any individual who does not fulfil the inclusion criteria
- •Temporary Exclusion Criteria:
- •Critically-ill patients and/or their family member will be only approached when the patient starts recovering from their illness or after they are deceased, on the advice of their clinical team.
结局指标
主要结局
informed consent obtained for all culture-confirmed IMD to sequence their genome.
时间窗: up to 55 months
enrol cases
次要结局
- creation of a functional database linking anonymised whole genome human and meningococcal sequences with data collected through national surveillance(up to 55 months)
- detailed genetic analysis on human-pathogen pairs, focussing particularly on (but not restricted to) the human complement system and the respective meningococcal binding proteins.(up to 55 months)
- visualising potential host-pathogen interactions through computer modelling(up to 55 months)