Magnesium Effect on Embryonal PR Interval
试验速览
- 阶段
- 不适用
- 入组人数
- 25
- 主要终点
- Prolonged PR interval
研究概览
简要总结
Magnesium is a known treatment for neuroprotection in preterm labor before 32 week of gestation. High concentration of Magnesium in the blood stream known as cause of conduction abnormalities and ECG changes such us prolonged QT, QRS and PR in about. The goal of our work is to evaluate the PR intervals in embryos after maternal treatment with magnesium during preterm labor.
详细描述
We will recruit 25 woman with threaten preterm labor, magnesium blood level and PR interval will be evaluated before magnesium loading dose (4gr) and 20 minutes after the loading dose.
PR interval will be evaluated by Mitral-Aorta Doppler.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Diagnostic
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 50 Years（Adult）
- 性别
- Female
- 接受健康志愿者
- 否
入选标准
- •Women at risk for preterm labor before 32 week of gestation
排除标准
- •Fetal malformations
- •Maternal Lupus
- •Fetal conduction abnormalities
结局指标
主要结局
Prolonged PR interval
时间窗: 20 min after magnesium treatment
PR will be measured by Mitral-aorta doppler
次要结局
未报告次要终点
研究者
Ola Gutzeit MD
Principal investigator
Rambam Health Care Campus