NCT04969523Unknown不适用
Effect of Es-ketamine on Postoperative Delirium Among Old Patients With Lobectomy: a Multicentre, Double-blind, Randomised Clinical Trial
Zhongnan Hospital0 个研究点目标入组 500 人开始时间: 2021年7月31日最近更新:
适应症
试验速览
- 阶段
- 不适用
- 发起方
- 入组人数
- 500
- 主要终点
- Postoperative Delirium
研究概览
简要总结
The purpose of this study is the efficiency of es-ketamine on postoperative delirium among old patients with elective lobectomy
详细描述
This study aimed to investigate the effect of IV es-ketamine vs saline on the incidence of postoperative delirium. It was hypothesized that IV es-ketamine would reduce the incidence of in-hospital delirium during cardiac surgery lobectomy
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Prevention
- 盲法
- Triple (Participant, Investigator, Outcomes Assessor)
入排标准
- 年龄范围
- 60 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •60 years old; There is no limit on the gender, ASA (American Society of Anesthesiologists )Ⅰ-Ⅲ
排除标准
- •Emergency surgery, severe hepatic and renal dysfunction, shock or coma, psychiatric disease or central nervous system disorder or a history of long-term use of psychiatric medications, cognitive dysfunction, severe arrhythmia or bradycardia, ketamine allergy,drug abuse history and used other sedatives for nearly a week
结局指标
主要结局
Postoperative Delirium
时间窗: 7 days after operation
Confusion Assessment Method (CAM) or CAM-ICU for patients
Postoperative Cognitive Assessment
时间窗: 7 days after operation
Montreal Cognitive Assessment
次要结局
未报告次要终点
研究者
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