NCT07271420招募中4 期
Blood Pressure Control With Thiazide Diuretics in Peritoneal Dialysis Patients
适应症
干预措施
试验速览
- 阶段
- 4 期
- 状态
- 招募中
- 入组人数
- 40
- 试验地点
- 1
- 主要终点
- Change in systolic and diastolic blood pressure
研究概览
简要总结
To evaluate the blood pressure lowering effects of thiazide diuretics in patients on peritoneal dialysis
详细描述
This prospective, single-center treatment-withdrawal crossover study enrolled 10 patients on chronic peritoneal dialysis (PD) and uncontrolled hypertension (SBP >140 mmHg and/or DBP >90 mmHg).
Following written informed consent, participants entered the treatment arm, receiving oral hydrochlorothiazide once daily on top of their standard of treatment for 90 days. This was followed by a 14-day washout period, after which participants entered a 90-day control period.
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Crossover
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients on chronic peritoneal dialysis, with uncontrolled hypertension (SBP >140 mmHg and/or DBP >90 mmHg)
排除标准
- •Patients with a life expectancy of less than 3 months, planned conversion to hemodialysis, or scheduled kidney transplantation within 3 months
研究组 & 干预措施
Thiazides treatment arm
Active Comparator
干预措施: Hydrochlorothiazide 25mg once per day (Drug)
结局指标
主要结局
Change in systolic and diastolic blood pressure
时间窗: 90 days
次要结局
- Changes in body composition measured by bio impedance spectroscopy(90 days)
- Changes in body weight(90 days)
- Change in urinary fractional excretion of sodium(90 days)
研究者
Chan Chun Kau Gordon
Dr
Chinese University of Hong Kong
研究点 (1)
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