"Assessment of Different Medications in Modifying the Efficacy of Anesthesia in Mandibular Molars With Acute Irreversible Pulpitis (A Randomized Clinical Trial)"
试验速览
- 阶段
- 4 期
- 状态
- 已完成
- 入组人数
- 60
- 试验地点
- 1
- 主要终点
- assess the effect of Preoperative administration of- Oral tablets of Trypsin/Chymotrypsin/Bromelain) - Regarding the efficacy of the inferior alveolar nerve block anesthesia in mandibular molars with symptomatic irreversible pulpitis
研究概览
简要总结
The goal of this clinical trial is to assess the effect of preoperative
- Oral Tablets of Trypsin/Chymotrypsin/Bromelain Limitless Allzyme® (15 microkatal/42microkatal/240 GDU)
- Oral tablets of Alphintern® (Trypsin/Chymotrypsin 5 micro Katals/14 micro Katals)
- Oral Tablets Non-Steroidal Anti-inflammatory drug (Cataflam® 50mg)
Regarding the efficacy of the inferior alveolar nerve block anesthesia in mandibular molars with symptomatic irreversible pulpitis and post operative pain follow up for 3 days.
The main question it aims to answer are: • Does premedication increase the success rate of inferior alveolar nerve block.
Participants will describe their preoperative pain level to the investigator and describe their pain level during the treatment. Researchers will compare different premedication to see if it increases the success rate of inferior alveolar nerve block using Visual Analogue Scale (VAS), Electric Pulp testing and cavity test.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Supportive Care
- 盲法
- Single (Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 65 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •• From 18 to 65 years old.
- •Both male and female participants were accepted.
- •Mandibular molars diagnosed with acute irreversible pulpitis.
- •Class I occlusion with normal occlusal contacts
排除标准
- •• Individuals with significant health issues: a history of gastrointestinal disorders, active bronchial asthma, renal diseases, liver dysfunction, heart diseases, blood disorders, hypertension or poorly controlled diabetes mellitus.
- •Immunocompromised patients.
- •Sensitivity or allergy to any of the pharmaceuticals or medications intended for use in the study
- •Participants who could not read, comprehend, or complete the baseline pain scale questionnaire.
- •Cases where clinical examination suggested necrotic teeth leading to a false positive diagnosis.
- •Teeth exhibiting periodontal disease or periapical lesions confirmed through clinical assessment and pre-operative radiographs.
- •Sensitivity to percussion or palpation in the included teeth
研究组 & 干预措施
Non-Steroidal Anti-inflammatory drug (Cataflam 50mg)
Received Cataflam
干预措施: Cataflam® 50 coated tablet (Drug)
Oral Tablets of Limitless Allzyme
干预措施: Limitless Allzyme (Drug)
Alphintern® (Trypsin/Chymotrypsin 5 micro Katals/14 micro Katals)
干预措施: Oral tablets of Alphintern® (Drug)
结局指标
主要结局
assess the effect of Preoperative administration of- Oral tablets of Trypsin/Chymotrypsin/Bromelain) - Regarding the efficacy of the inferior alveolar nerve block anesthesia in mandibular molars with symptomatic irreversible pulpitis
时间窗: Up to 30 minutes from lip numbness until the end of pulp exacerbation and post operative pain follow up for 3 days.
Assessment of outcome is done using cavity test.
次要结局
未报告次要终点