NCT00131014招募中不适用
Establishing a Tumor Bank and Initial Analysis of Germline and Tumor-Related Genetic Alterations in Families With Multiple Lymphoproliferative Malignancies
适应症
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 1,500
- 试验地点
- 2
- 主要终点
- Genetic factors that contribute to the development of lymphomas and CLL
研究概览
简要总结
The purpose of this study is to investigate possible genetic factors that contribute to the development of lymphomas. The databank will be used to determine whether familial lymphomas have unique genetic characteristics different from sporadic lymphomas and to attempt to identify a gene that confers an increased risk of lymphoma.
详细描述
- Patients who participate will be asked to complete detailed family and medical history questionnaires initially, with a follow-up questionnaire every year.
- Patients will be asked to supply a blood sample and possibly a mouthwash sample, both of which can be done by mail.
- Patients will be asked to consent to the release of their lymphoma tissue block for the purposes of the study.
- Patients will be given letters of invitation for their affected relatives to invite them to participate.
研究设计
- 研究类型
- Observational
- 观察模型
- Family Based
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Any individual diagnosed with non-Hodgkin's lymphoma or Hodgkin's disease or chronic lymphocytic leukemia (CLL), who has a 1st degree relative (parent, sibling or child) with a lymphoproliferative disorder; or families in which the individual has a lymphoproliferative disorder, and an unusual clustering of frequent or premature solid tumors is also observed.
- •Family members of the individual, either affected or unaffected with lymphoma, who are contacted by the individual and agree to participate in the study.
- •Deceased family members may be included in the study. Public records such as death certificates may be used to confirm the history. Consent for medical records or tissue blocks will be obtained from the deceased family member's next of kin. The hierarchy of relatives defined as next of kin is spouse, offspring, parents and siblings. Archived tissue samples may be used for genetic research.
- •Age > 18 years
排除标准
- •Subjects without a family history of lymphoma
研究组 & 干预措施
Subject affected by lymphoma
Subject affected by lymphoma
Next of Kin of deceased subj by lymphoma
Next of Kin of deceased subject by lymphoma
Subject unaffected by lymphoma
Subject unaffected by lymphoma
结局指标
主要结局
Genetic factors that contribute to the development of lymphomas and CLL
时间窗: Indefinite
Genetic factors that contribute to the development of lymphomas and CLL
次要结局
未报告次要终点
研究者
Jennifer R. Brown, MD, PhD
Assistant Professor of Medicine
Dana-Farber Cancer Institute
研究点 (2)
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