NCT02909075已完成不适用
An Initial Study of FDG-PET/CT and MRI to Assess Thymic Function
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 3
- 试验地点
- 3
- 主要终点
- change in thymic size
研究概览
简要总结
The purpose of this study is to see if a positron emission tomography/computed tomography (PET/CT) scan and a magnetic resonance imaging (MRI) of the chest can assess changes in the thymus size and function. The researchers would like to monitor the thymus with a PET/CT scan and a MRI before and after the participants transplantation.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 65 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patient's age is ≥18 or ≤65 years old.
- •Patients must have a plan to receive a CD34-selected peripheral blood stem cell graft.
排除标准
- •Patient is not able to undergo MR imaging due to any contraindication to MRI based on departmental MR questionnaire (e.g. past gadolinium allergies, failure of metallic screening, claustrophobia, inability to lay flat for duration of the study, inability to hold breath, etc.)
- •Pregnant or breastfeeding.
结局指标
主要结局
change in thymic size
时间窗: 1 year
A clinically meaningful change is defined as increase in thymic size (\> 0.2cm increase in uni-dimensional diameter), functional volume (\>10%) or uptake (≥25%). We will report proportion of patients with each component of clinically meaningful change, as well as the proportion with at least one component, along 95% exact confidence intervals.
次要结局
未报告次要终点
研究者
研究点 (3)
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