NCT05768529招募中1 期
A Single-arm, Open and Multicenter Phase I/II Clinical Study to Evaluate the Safety and Efficacy of U16 Injection in the Treatment of Refractory/Recurrent B-cell Non-Hodgkin's Lymphoma (r/r B-NHL)
Shanghai Unicar-Therapy Bio-medicine Technology Co.,Ltd2 个研究点 分布在 1 个国家目标入组 100 人开始时间: 2023年3月28日最近更新:
适应症
干预措施
相关药物
试验速览
- 阶段
- 1 期
- 状态
- 招募中
- 发起方
- 入组人数
- 100
- 试验地点
- 2
- 主要终点
- Overall Remission Rate (ORR)
研究概览
简要总结
The study is a Phase I/II, single-arm, open-label clinical trial, and its primary objective of phase I and phase II is to evaluate the safety and efficacy of U16 Injection in the treatment of relapsed or refractory NHL,respectively.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 70 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients who are willing to sign the informed consent form and have good compliance;
- •Aged 18-70 years, male or female;
- •CD20-positive B-cell non-Hodgkin's lymphoma with immunohistochemistry(IHC), with the following diagnostic: Diffuse large B cell lymphoma (DLBCL), or Primary mediastinal large B cell lymphoma (PMBCL), or Follicular lymphoma transformed large B cell lymphoma (TFL) , or High grade B cell lymphoma(HGBCL);
- •Previously received≥2nd-line adequate therapy or autologous hematopoietic stem cell transplantation (ASCT), including: a) Received anthracycline-containing drugs and rituximab or other CD20-targeted drugs (except CD20-negative tumors); b) Definition of line: Stable disease (SD) after receiving a first-line therapy for at least 4 cycles or progressive disease (PD), and SD after a second-line therapy for at least 2 cycles or PD; c) For transformed follicular lymphoma (TFL), patients must be treated adequately against FL, and after transformation, must have received at least once the therapy against TFL, and become relapsed or refractory after the last therapy;
- •In relapsed or refractory status at screening: a) Definition of relapse: Remission (including partial remission (PR) or complete remission (CR)) after treatment with at least the standard therapy regimen, and then PD; b)Definition of refractory: i. Non-response to the last therapy: The best response by the last therapy is SD or PD, and the duration is less than 6 months; ii. Relapse or progression (it must be proved by biopsy) after ASCT, including: Relapse or PD within 12 months after ASCT; if a salvage therapy is received, the patient is non-response (SD or PD) to the last therapy;
- •According to Lugano Criteria (Cheson2014), at least one measurable lesion exists；
- •Eastern Cooperative Oncology Group (ECOG) performance status of 0-1;
- •Adequate bone marrow reserve, defined as: Absolute neutrophil count (ANC) ≥1.0×10^9/L; Absolute lymphocyte count (ALC) ≥ 0.3×10^9/L; Platelet (PLT) ≥50×10^9/L;
- •Proper organ function, defined as: Aspartate aminotransferase (AST) ≤ 3 Upper Limit of Normal (ULN); Alanine aminotransferase (ALT) ≤ 3 ULN(AST and ALT≤5 ULN are required for the patients with hepatic dysfunction due to tumor cell infiltration) ; Total serum bilirubin ≤ 2 ULN, unless there exists concurrent Gilbert syndrome; patients with Gilbert syndrome, with total serum bilirubin ≤ 3 ULN and direct bilirubin ≤ 1.5 ULN, may be included; Serum creatinine ≤ 1.5 ULN or creatinine clearance ≥ 60 mL/min (Cockcroft-Gault formula); Minimum pulmonary reserve, defined as Grade ≤ 1 dyspnea, and blood oxygen saturation > 91% at non-oxygen inhalation status;
- •Women with child-bearing potential are negative in blood/urine pregnancy tests within 7 d prior to infusion of U16 infusion; any male or female patient with child-bearing potential must agree to adopt effective contraceptive measures throughout the study, and at least one year after administration of the investigational therapy.
- •Qualified T cell function;
- •Vascular conditions for apheresis, and no other contraindications for apheresis;
- •Elution period of CD20 monoclonal antibody at least 3 months before U16 infusion;
- •Life expectancy more than 3 months.
排除标准
- •Patients with other malignant tumors, except for disease-free survival for more than 3 years or carcinoma in-situ;
- •Patients with lymphoma involved with atrium or ventricle；
- •Used immunosuppressants, hormones or high-dose chemotherapy within 2 weeks before signing the informed consent form, or planned to use immunosuppressants or hormones(specifically referring to systemic therapy) before apheresis, except for local or inhaled corticosteroid therapy;
- •Patients complying with any of hepatitis B surface antigen (HBsAg) and/or hepatitis B e antigen (HBeAg) positive; hepatitis B e antibody (HBe-Ab) and/or hepatitis B core antibody (HBc-Ab) positive and HBV-DNA copies being more than the lower limit of detection; hepatitis C antibody (HCV-Ab) positive and HBV-RNA copies being more than the lower limit of detection; anti-treponemia pallidum antibody (TP-Ab) positive; Human immunodeficiency virus (HIV) antibody positive; EBV-DNA, and CMV-DNA copies being more than the lower limit of detection;
- •Patients with bacteria, fungi, viruses, mycoplasma or other types of infections, and difficult for controlling by researcher's judgment;
- •Patients with active primary or secondary central nervous system (CNS) lymphoma (a patient with CNS disease symptoms must receive lumbar puncture to exclude CNS lymphoma)；
- •Patients with existing central nervous system disease or with a history of central nervous system disease, e.g., epileptic seizure, cerebral ischemia/hemorrhage, dementia, cerebellum disease, or any autoimmune disease involved with central nervous system；
- •Patients with cardiac angioplasty or stent implantation within 12 months before signing the informed consent form, or myocardial infarction, unstable angina pectoris, other clinically significant heart disease history judged by researcher;
- •Patients need urgent clinical emergencies (such as intestinal obstruction or vascular compression, etc.) due to the obstruction or compression of lymphoma judged by researcher;
- •Patients previously received CAR-T cell therapy with CD20 target;
- •Patients with primary immunodeficiency;
- •Patients who are known with a history of hypersensitivity reaction to any ingredient used for the drug product in the trial.;
- •Patients vaccinated with a live vaccine within 6 weeks prior to screening;
- •Pregnant or lactating women;
- •Patients with active autoimmune diseases;
- •Patients with active acute or chronic graft-versus-host disease (GVHD) when signing the informed consent form;
- •Received allogeneic hematopoietic stem cell transplantation within 6 months before signing the informed consent form;
- •Participated in any other clinical trial within 30 days before signing the i informed consent form;
- •Patients with other conditions that are not suitable to participate in the clinical trial, as considered by the investigator.
研究组 & 干预措施
U16
Experimental
Route of administration: Intravenous injection.
Lymphodepletion conditioning:
Lymphodepletion will be conducted several days prior to U16 infusion.
A combination of fludarabine and cyclophosphamide will be used for lymphodepletion.
干预措施: U16 (Drug)
结局指标
主要结局
Overall Remission Rate (ORR)
时间窗: 3 months
Efficacy of U16 as measured by ORR during the 3 months after U16 Injection infusion, which includes CR and PR.
Types, frequency and severity of adverse events
时间窗: 24 months
Safty of U16 as measured by types, frequency and severity of adverse events after U16 Injection infusion.
次要结局
- Complete Remission (CR)(3 months)
- Duration of Remission (DOR)(24 months)
- Pharmacokinetic (PK)- AUC(24 months)
- Progression-free survival (PFS)(24 months)
- Pharmacokinetic (PK)- Cmax(24 months)
- Pharmacokinetic (PK)- Tmax(24 months)
- Concentration of Cytokines in Serum(24 months)
- Overall Survival（OS）(24 months)
- Concentration of B cells(24 months)
研究者
研究点 (2)
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