NCT02496455已完成不适用
The Impact of the Single Nucleotide Polymorphisms rs6746030,rs7604448, rs10930214, s7595255 in SCN9A Gene on Postoperative Pain and Analgesic Consumption After Cesarean Section
Tokat Gaziosmanpasa University1 个研究点 分布在 1 个国家目标入组 200 人开始时间: 2015年8月最近更新:
适应症
相关药物
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 200
- 试验地点
- 1
- 主要终点
- Pain
研究概览
简要总结
The purpose of this study to determine the association between postoperative pain after cesarean section and several single nucleotide polymorphisms in SCN9A sodium channels gene.
详细描述
SCN9A gene encodes an alpha subunit of the voltage-gated sodium channel (Nav1.7) and polymorphisms of this gene are associated with severe pain disorders. The impact of the polymorphisms in SCN9A on postoperative pain and opioid consumption after cesarean section is unclear.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 45 Years（Adult）
- 性别
- Female
- 接受健康志愿者
- 否
入选标准
- •The women aged 18 to 45,
- •in 36 to 40 weeks of pregnancy
- •undergoing cesarean section
排除标准
- •History of chronic pain or pain disorders
- •Psychiatric diseases
- •Diabetes mellitus
- •Severe cardiovascular, kidney or liver diseases
- •Alcohol or drug abuse
- •Heavy smoker
- •Unable to use the Patient controlled analgesia (PCA) pump
结局指标
主要结局
Pain
时间窗: up to postoperative 24 hours
The pain will be evaluated with the visual analog scale
次要结局
- Opioid consumption(Up to postoperative 24 hours)
研究者
Tuğba Karaman
Assistant Professor, M.D.
Tokat Gaziosmanpasa University
研究点 (1)
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