A Phase Ib/IIa Single Centre, Double-blind, Double-dummy, Placebo-controlled, Parallel-group Dose Ranging Trial in Adult Participants With Uncomplicated Dengue Fever in Singapore
试验速览
- 阶段
- 1 期
- 状态
- 撤回
- 试验地点
- 1
- 主要终点
- Viral load AUC for viremia
研究概览
简要总结
Dengue fever is an acute febrile illness transmitted by mosquitoes, which affects half the world's population. There are 96 million symptomatic infections, 500,0000 hospitalisations and 25,000 deaths per year attributed to the disease. The economic burden is $12 billion. In Singapore, as elsewhere, the incidence of the disease continues to increase despite aggressive control measures. At present there are no approved medicines for treating dengue fever. Only supportive fluid replacement therapy is used to treat vascular leakage in patients with severe illness. Therefore there is an urgent need to find alternative treatments. Experiments in the laboratory have shown that Celgosivir and modipafant inhibit dengue virus and improve mouse survival. Both drugs have previously been used in humans with good safety records, so investigators are taking this one step further to find out how well it works in dengue patients. Investigators plan to enroll dengue patients within 48 hours of fever onset and assign them to one of four treatment groups over five days. Together with the support from the industry partner, 60°Pharmaceuticals PLC, the investigators will determine the safety and effectiveness of these drugs on acute dengue patients and pave the way forward for dengue antiviral medicines to reach patients.
详细描述
This trial is a single centre, double-blind, double-dummy, placebo-controlled parallel-group, dose ranging study in adult participants with uncomplicated dengue fever. The study will be conducted in two parts:
In Part 1, 72 otherwise healthy participants (18 participants per group, assuming up to 2 dropouts per group) with uncomplicated dengue fever meeting the inclusion/exclusion criteria will be randomised to receive treatment with placebo, celgosivir or modipafant. Participants will be randomised in parallel to one of Cohorts 1 to 4:
- Cohort 1: Placebo Q6Hours for 5 days
- Cohort 2: Modipafant 50 mg Q12Hours alternating with placebo Q12Hours for 5 days (total of 10 modipafant doses = 500 mg);
- Cohort 3: Modipafant 100 mg Q12Hours alternating with placebo Q12Hours 5 days (total of 10 modipafant doses = 1000 mg);
- Cohort 4: Celgosivir 150 mg Q6H for 5 days (total of 20 doses = 3000 mg total).
As modipafant is untested in uncomplicated dengue fever patients, a double-blinded sentinel group consisting of 4 participants randomised in a 1:1:1:1 ratio of Cohort 1: Cohort 2: Cohort 3: Cohort 4 will complete treatment to Study Day 5 prior to continuing enrolment of the remaining participants. Remaining 68 participants will be enrolled in parallel in a double-blinded fashion.
Participants will be evaluated during screening (< 24 hours before Study Day 1) and on Study Days 1-5, 14 and 28. Participants will be confined in the SingHealth Investigational Medicine Unit (IMU) from screening until end of study assessments on Study Day 5 and return to the clinic at Day 14 and 28 as outpatients. All patients will receive capsules Q6H for 5 days prepared by an open-label pharmacist according to the randomisation plan.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Triple (Participant, Care Provider, Investigator)
入排标准
- 年龄范围
- 21 Years 至 65 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Male or female, aged 21-65 years;
- •Acute febrile illness with two or more manifestations (headache, retro-orbital pain, myalgia, arthralgia, rash, haemorrhagic manifestations, or leucopoenia) and occurrence at the same location and time as other confirmed cases of dengue fever;
- •Fever (> 37.5°C) or history of fever at screening
- •< 48 hours of fever history
- •Positive NS1 strip assay or reverse-transcriptase polymerase chain reaction (RT-PCR).
- •Able and willing to give written informed consent; and,
- •Willing to be an inpatient from Study Screening to Study Day 5 and to return to hospital on study Days 14 and
- •Willing to keep a study diary from Study Day 5 to Day 14.
排除标准
- •Clinical signs and symptoms for severe dengue, such as:
- •Severe abdominal pain;
- •Persistent vomiting;
- •CS fluid accumulation;
- •Mucosal bleeding;
- •Altered mental state;
- •Liver enlargement > 2 cm;
- •Systolic blood pressure < 90 mmHg; and
- •Pulse pressure < 20 mmHg.
- •A person with any of the following laboratory values:
- •Haematocrit >52% males; >46% females;
- •Aspartate or alanine aminotransferase (AST or ALT) > 1000 U/L;
- •Room air oxygen saturation < 95%;
- •Absolute neutrophil count < 1500/µL;
- •Platelet count < 80,000/mm3;
- •Creatinine > 165 µmol/L males; > 130 µmol/L females;
- •Haemoglobin < 13.0 g/dL males; < 11.0 g/dL females;
- •Total bilirubin > 24 µmol/L; and
- •Serum CPK > 600 U/L.
- •History of or presently active intestinal disorders such as peptic ulcers, intestinal ulcers, intestinal obstructions, intestinal hernias, ulcerative colitis, malabsorption syndrome, celiac disease, Roemheld's syndrome (gastroesophageal regurgitation disease) or Crohn's disease;
- •Severe diarrhoea (grade 2 or higher according to NIH clinical trial guidelines);
- •Current usage of any anticoagulant drugs including, but not limited to, aspirin, warfarin or clopidogrel;
- •Any other CS acute illness within seven days prior to first study drug administration;
- •History of adverse reactions to celgosivir, castanospermine, modipafant or formulation excipients or history of severe drug or food allergies;
- •Exposure to any new investigational drug within 30 days prior to the study drug administration;
- •CS abnormal physical examination unrelated to dengue infection, chest X-ray or 12-lead ECG at screening such as QTc prolongation (> 450 msec);
- •Women of child bearing potential (WOCBP) who are pregnant, breast feeding or unwilling to avoid pregnancy by the use of highly effective contraception (<1% failure rate per year) including oral and subcutaneous implantable hormonal contraceptives, condoms, diaphragm, or intra-uterine system (IUS), during the period that the experimental drug is administered. Prospective WOCBP must have a negative pregnancy test (point of care).
- •Male participants unwilling to comply with the contraceptive requirements of the study as detailed in Section 4.7 (i.e. abstinence, effective barrier contraception during the study and for 65 days after the last dose of study drug).
- •Current significant medical condition or illness including cardiac arrhythmias, cardiomyopathy or other cardiac disease, asthma or other respiratory disease, diabetes mellitus, renal or hepatic impairment, thyroid disease, Parkinson's disease, epilepsy or history of unexplained blackouts, immunocompromised state including known HIV infection, or any other illness that the Investigator considers should exclude the patient, especially those that require continuation of other medications likely to have an interaction with the study drug.
- •Any condition that would render the informed consent invalid, or limit the ability of the participant to comply with the study requirements.
- •Any condition that, in the opinion of the Investigator, would complicate or compromise the study or well-being of the participant.
研究组 & 干预措施
Cohort 1
Placebo Q6H for 5 days
A total of 72 participants (18 participants per group assuming up to two drop-outs per group) will be assigned in a randomised double-blind fashion.
干预措施: Placebo (Drug)
Cohort 2
Modipafant 50 mg Q12H alternating with placebo Q12H for 5 days (total of 10 modipafant doses = 500 mg)
干预措施: Modipafant 50mg (Drug)
Cohort 3
Modipafant 100 mg Q12H alternating with placebo Q12H 5 days (total of 10 modipafant doses = 1000 mg)
干预措施: Modipafant 100mg (Drug)
Cohort 4
Celgosivir 150 mg Q6H for 5 days (total of 20 doses = 3000 mg total).
干预措施: Celgosivir (Drug)
结局指标
主要结局
Viral load AUC for viremia
时间窗: Day 1 to Day 5
Area under the curve (AUC) for serum viral load from baseline to Study Day 5 of Celgosivir dosing
Platelet nadir
时间窗: Day 1 to Day 5
Lowest platelet count recorded from baseline to Study Day 5 of Modipafant dosing
次要结局
- Fever clearance time (days)(Day 1 to 28)
- Duration of illness(Day 1 to 28)
- Maximum percentage haemoconcentration(Day 1 to 28)
- Time to NS1 clearance(Day 1 to 28)